N E Price,M C Mumby
N E Price
All of the known protein serine/threonine phosphatases are expressed in the brain. These enzymes participate in a variety of signaling pathways that modulate neuronal activity. The multifunctional activity of many serine/threonine phosphata...
R S Puranam,J O McNamara
R S Puranam
The rate at which mutant genes producing an epileptic phenotype in mice have been identified over the past few years has been astounding. Manipulating the genome of mice has led to identification of a diversity of genes whose absence or mod...
H J Song,M M Poo
H J Song
Many diffusible axon guidance cues and their receptors have been identified recently. These cues are often found to be bifunctional, acting as attractants or repellents under different circumstances. Studies of cytoplasmic signaling mechani...
V N Murthy
V N Murthy
Recent advances in optical methods have catalyzed a detailed study of individual visualized synapses in several model systems. Quantal events at small central synapses, as well as single granule exocytosis in secretory cells, have been dete...
K M Harris
K M Harris
Dendritic spines are distinguished by their shapes, subcellular composition, and synaptic receptor subtypes. Recent studies show that actin-dependent movements take place in spine heads, that spines emerge from stubby and shaft synapses aft...
R S Zucker
R S Zucker
Calcium ions play crucial signaling roles in many forms of activity-dependent synaptic plasticity. Recent presynaptic [Ca2+]i measurements and manipulation of presynaptic exogenous buffers reveal roles for residual [Ca2+]i following conditi...
S M Bajjalieh
S M Bajjalieh
Neurotransmitter secretion shares many features with constitutive membrane trafficking. In both cases, vesicles are targeted to a specific acceptor membrane and fuse via a series of protein-protein interactions. Recent work has added to the...
The bacterial K+ channel structure and its implications for neuronal channels [0.03%]
细菌K+通道结构及其对神经元通道的意义
G Yellen
G Yellen
Voltage-gated K+ (Kv) channels play a central role in generating action potentials and rhythmic patterns, as well as in dendritic signal processing in neurons. Recently, the first structure of a member of the K+ channel family was solved. A...
D E Bergles,J S Diamond,C E Jahr
D E Bergles
The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished - indeed, new evidence is fanning the flames. Recent experiments using two-photon microscopy suggest that the concentration of glut...
J Kirsch
J Kirsch
The postsynaptic membrane and the subsynaptic cell compartment are specialized for inter- and intracellular signaling. Recent work has focused on the role of synaptic activity in regulating the surface distribution of neurotransmitter recep...