James K Rilling,Brooks King-Casas,Alan G Sanfey
James K Rilling
Humans live in highly complex social environments and some of our most important decisions are made in the context of social interactions. Research that probes the neural basis of decision-making in the context of social interactions combin...
Michael Andäng,Urban Lendahl
Michael Andäng
The brain develops and functions in a complex ionic milieu, which is a prerequisite for neurotransmitter function and neuronal signaling. Neurotransmitters and ion fluxes are, however, important not only in neuronal signaling, but also in t...
Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans [0.03%]
从秀丽隐杆线虫构建突触：关于突触特异性和前突触装配的启示
Milica A Margeta,Kang Shen,Brock Grill
Milica A Margeta
Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning an...
S Sean Millard,S Lawrence Zipursky
S Sean Millard
Recent studies have uncovered the molecular basis of self-avoidance and tiling, two fundamental principles required for the formation of neural circuits. Both of these wiring strategies are established through homophilic repulsion between D...
Hirofumi Morishita,Takao K Hensch
Hirofumi Morishita
Neural circuits are shaped by experience in early postnatal life. The permanent loss of visual acuity (amblyopia) and anatomical remodeling within primary visual cortex following monocular deprivation is a classic example of critical period...
Dennis Dm O&#x;Leary,Setsuko Sahara
Dennis Dm O&#x;Leary
Arealization of the neocortex is controlled by a regulatory hierarchy beginning with morphogens secreted from patterning centers positioned at the perimeter of the dorsal telencephalon. These morphogens act in part to establish within corti...
Transcriptional mechanisms controlling motor neuron diversity and connectivity [0.03%]
控制运动神经元多样性和连接性的转录机制
Simon A Dalla Torre di Sanguinetto,Jeremy S Dasen,Silvia Arber
Simon A Dalla Torre di Sanguinetto
The control of movement relies on the precision with which motor circuits are assembled during development. Spinal motor neurons (MNs) provide the trigger to signal the appropriate sequence of muscle contractions and initiate movement. This...
New insights into the molecular mechanisms specifying neuronal polarity in vivo [0.03%]
体内指定神经元极性的分子机制的新见解
Anthony P Barnes,David Solecki,Franck Polleux
Anthony P Barnes
The polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain. Important progress has been made toward the identification of the molecular mechanisms regulating neuronal polarizat...
Xin Duan,Eunchai Kang,Cindy Y Liu et al.
Xin Duan et al.
New neurons are continuously generated in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles throughout life. The origin of these new neurons is believed to be from multipotent adult neur...
Weimin Zhong,William Chia
Weimin Zhong
The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial...