Sensory neuron voltage-gated sodium channels as analgesic drug targets [0.03%]
疼痛药物作用靶点：感觉神经元电压门控钠通道
Aliakmal Momin,John N Wood
Aliakmal Momin
Voltage-gated sodium channels are crucial determinants of neuronal excitability and signalling; some specific channel subtypes have been implicated in a number of chronic pain conditions. Human genetic studies show gain-of-function or loss-...
Holly Bridge,Bruce G Cumming
Holly Bridge
Useful representations of the three-dimensional (3D) world go beyond assigning depth to individual points, building maps of surfaces and shapes. Studies in a wide range of extrastriate cortical areas have shown that single neurons show sele...
Peter Dallos
Peter Dallos
Mechanical amplification of acoustic signals is apparently a common feature of vertebrate auditory organs. In non-mammalian vertebrates amplification is produced by stereociliary processes, related to the mechanotransducer channel complex a...
Mehrdad Jazayeri
Mehrdad Jazayeri
A hallmark of higher brain functions is the ability to contemplate the world rather than to respond reflexively to it. To do so, the nervous system makes use of a modular architecture in which sensory representations are dissociated from ar...
Rachel I Wilson
Rachel I Wilson
Recent in vivo and in vitro studies have challenged existing models of olfactory processing in the vertebrate olfactory bulb and insect antennal lobe. Whereas lateral connectivity between olfactory glomeruli was previously thought to form a...
Steven Hsiao
Steven Hsiao
Studies show that while the cortical mechanisms of two-dimensional (2D) form and motion processing are similar in touch and vision, the mechanisms of three-dimensional (3D) shape processing are different. 2D form and motion are processed in...
Farran Briggs,W Martin Usrey
Farran Briggs
Although it is now generally accepted that the thalamus is more than a simple relay of sensory signals to the cortex, we are just beginning to gain an understanding of how corticothalamic feedback influences sensory processing. Results from...
Israel Nelken
Israel Nelken
The coding of complex sounds in the early auditory system has a 'standard model' based on the known physiology of the cochlea and main brainstem pathways. This model accounts for a wide range of perceptual capabilities. It is generally acce...
Matthew E Larkum,Thomas Nevian
Matthew E Larkum
Dendritic signal integration is one of the fundamental building blocks of information processing in the brain. Dendrites are endowed with mechanisms of nonlinear summation of synaptic inputs leading to regenerative dendritic events includin...
Jeff W Lichtman,Joshua R Sanes
Jeff W Lichtman
Some neuroscientists argue that detailed maps of synaptic connectivity--wiring diagrams--will be needed if we are to understand how the brain underlies behavior and how brain malfunctions underlie behavioral disorders. Such large-scale circ...