Ingo H Greger,José A Esteban
Ingo H Greger
AMPA-type glutamate receptors mediate the majority of fast excitatory transmission in the central nervous system. The trafficking of AMPA receptors to and from synapses alters synaptic strength and has been recognized as a central mechanism...
Jianhua Xu,Liming He,Ling-Gang Wu
Jianhua Xu
Repetitive nerve activity induces various forms of short-term synaptic plasticity that have important computational roles in neuronal networks. Several forms of short-term plasticity are caused largely by changes in transmitter release, but...
Gina Turrigiano
Gina Turrigiano
Synaptic homeostasis provides a means for neurons and circuits to maintain stable function in the face of perturbations such as developmental or activity-dependent changes in synapse number or strength. These forms of plasticity are thought...
Brenda L Bloodgood,Bernardo L Sabatini
Brenda L Bloodgood
Recent studies have revealed that Ca(2+) signals evoked by action potentials or by synaptic activity within individual dendritic spines are regulated at multiple levels. Ca(2+) influx through glutamate receptors and voltage-sensitive Ca(2+)...
Susan M Voglmaier,Robert H Edwards
Susan M Voglmaier
At a wide range of synapses, synaptic vesicles reside in distinct pools that respond to different stimuli. The recycling pool supplies the vesicles required for release in response to modest stimulation, whereas the reserve pool is mobilize...
Daniel Ulrich,Bernhard Bettler
Daniel Ulrich
GABA(B) receptors are the G-protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the mammalian central nervous system. They are implicated in a variety of neurological and psychiatric disorders. With the cloning of GA...
Ottavio Arancio,Moses V Chao
Ottavio Arancio
The growing realization that neurotrophins, such as brain-derived neurotrophic factor (BDNF), are crucial in modulating synaptic plasticity has broadened the spectrum of their trophic actions. At the same time, it has become clear that Abet...
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities [0.03%]
钙离子辅助受体驱动的内源大麻素释放：联结突触前膜和后膜活性的机制
Yuki Hashimotodani,Takako Ohno-Shosaku,Masanobu Kano
Yuki Hashimotodani
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. They are released from postsynaptic neurons and cause transient and long-lasting reduction of neurotransmitter release th...
Structural aspects of AMPA receptor activation, desensitization and deactivation [0.03%]
AMPA受体激活、脱敏感和失活的结构方面研究
Kasper B Hansen,Hongjie Yuan,Stephen F Traynelis
Kasper B Hansen
Glutamate mediates most of the excitatory neurotransmission in the mammalian central nervous system by activating ionotropic glutamate receptors. Structural and functional studies of ionotropic glutamate receptors have offered detailed insi...
Kazuo Okanoya
Kazuo Okanoya
Much debate has been stimulated by the recent hypothesis that human language consists of a faculty that is shared with non-human animals (faculty of language in a broad sense; FLB) and a faculty that is specific to human language (faculty o...