Michael Brecht
Michael Brecht
Neural networks of the rodent barrel cortex are particularly tractable for developing a quantitative understanding of response transformations in a cortical column. A column in barrel cortex consists of approximately 10 compartments. Two th...
Jan Benda,Tim Gollisch,Christian K Machens et al.
Jan Benda et al.
Sensory systems extract behaviorally relevant information from a continuous stream of complex high-dimensional input signals. Understanding the detailed dynamics and precise neural code, even of a single neuron, is therefore a non-trivial t...
Signalling mechanisms [0.03%]
信号传导机制
Stuart Cull-Candy,Rüdiger Klein
Stuart Cull-Candy
Gonzalo E Torres,Susan G Amara
Gonzalo E Torres
Neurotransmitters are rapidly removed from the extracellular space primarily through the actions of plasma membrane transporters. This uptake process is not only essential in the termination of neurotransmission but also serves to replenish...
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease [0.03%]
Parkinson病中的Pink1、Parkin、DJ-1和线粒体功能障碍
Mark W Dodson,Ming Guo
Mark W Dodson
Mutations in PARKIN, PTEN-induced kinase 1 (PINK1) and DJ-1 are found in autosomal recessive forms and some sporadic cases of Parkinson's disease. Recent work on these genes underscores the central importance of mitochondrial dysfunction an...
High-resolution quantitative visualization of glutamate and GABA receptors at central synapses [0.03%]
中枢突触谷氨酸和GABA受体的高分辨率定量可视化技术
Miwako Masugi-Tokita,Ryuichi Shigemoto
Miwako Masugi-Tokita
Glutamate and GABA are the main transmitters in the central nervous system and their effects are mediated by ionotropic and metabotropic receptors. Immunogold electron microscopy has revealed the quantitative localization of these receptors...
Mark Mayford
Mark Mayford
The relay of extracellular signals into changes in cellular physiology involves a Byzantine array of intracellular signaling pathways, of which cytoplasmic protein kinases are a crucial component. In the nervous system, a great deal of effo...
Jennifer Bourne,Kristen M Harris
Jennifer Bourne
Dendritic spines are the primary site of excitatory input on most principal neurons. Long-lasting changes in synaptic activity are accompanied by alterations in spine shape, size and number. The responsiveness of thin spines to increases an...
Differential regulation at functionally divergent release sites along a common axon [0.03%]
功能分化释放位点的差异化调控共用轴突沿长度分布广泛
Kenneth A Pelkey,Chris J McBain
Kenneth A Pelkey
Information transfer within neuronal networks requires the precise coordination of distinct neuronal populations within a given circuit. Evidence from a variety of central pathways indicates that such coordination is mediated in part by the...
Signaling in adult neurogenesis: from stem cell niche to neuronal networks [0.03%]
成人神经发生信号转导：从干细胞生态位到神经网络
Jovica Ninkovic,Magdalena Götz
Jovica Ninkovic
The mechanisms that determine why neurogenesis is restricted to few regions of the adult brain in mammals, in contrast to its more widespread nature in other vertebrates such as zebrafish, remain to be fully understood. The local environmen...