Inference problems in population genetics: DNA sequences, restriction endonucleases and ascertainment sampling [0.03%]
群体遗传学中的推理问题：DNA序列、限制性内切酶和抽样检测方法
W J Ewens
W J Ewens
A major trend of population genetics theory in the 1970s was the increased emphasis on inductive arguments, based on observed genetic data, rather than on deductive arguments based on theory and models. This occurred in part because the ded...
Morphological and physiological changes in dissociated adult frog muscle fibres after prolonged culturing [0.03%]
长时间培养后分离的成年青蛙肌纤维的形态和生理变化
M I Glavinović,R Miledi,Y Nakajima
M I Glavinović
Adult frog (Rana temporaria) muscle fibres, denervated in vivo, were dissociated and maintained in culture for several weeks. Light and electron microscopical studies showed that the fibres developed striated muscle sprouts. These sprouts w...
G M Housley,G V Born
G M Housley
We have reported that the antihaemolytic effect of low concentrations of chlorpromazine is decreased after enzymic removal of sialopeptides from red cell membranes, suggesting that an interaction between negatively charged sialic acids and ...
Large layer VI neurons of monkey striate cortex (Meynert cells) project to the superior colliculus [0.03%]
猕猴纹状皮层的大层VI神经元（Meynert细胞）投射至上丘
W Fries,H Distel
W Fries
After injections of the enzyme horseradish peroxidase (HRP) into the superior colliculus of macaque monkeys, labelled cells in the neocortex were found to be restricted to layer V in all areas except striate visual cortex. In striate visual...
Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes [0.03%]
外源性信使RNA在非洲爪蟾卵母细胞中诱导的五羟色胺受体
C B Gundersen,R Miledi,I Parker
C B Gundersen
When poly(A)+-mRNA, extracted from rat brain, was injected into Xenopus laevis oocytes, it induced the appearance of serotonin receptors in the oocyte membrane. Application of serotonin to injected oocytes elicited, after a long delay, osci...
Carotenoid pigments: their possible role in protecting against photooxidation in eyes and photoreceptor cells [0.03%]
类胡萝卜素色素：其可能在眼睛和光受体细胞抗氧化防变性中的作用
K Kirschfeld
K Kirschfeld
The effect of light on animal tissues is ambivalent. Light is necessary for many functions, e.g. for vision and, as in the flagellate halobacterium, to gain energy. But light is potentially dangerous: it is capable of destroying cells or th...
Ouabain-insensitive net sodium influx in erythrocytes of normotensive and essential hypertensive humans [0.03%]
正常血压和原发性高血压人类红细胞中ouabain不可逆的净钠流入
R I Birks,S Langlois
R I Birks
The Na+ content of erythrocytes is elevated in people with essential hypertension. There is conflicting evidence about its cause. The present study was designed to investigate whether the increase in content is due to a defect in a ouabain-...
Dissection of stages in exocytosis in the adrenal chromaffin cell with use of trifluoperazine [0.03%]
三氟拉嗪在肾上腺嗜铬细胞外泌作用各个阶段的研究
R D Burgoyne,M J Geisow,J Barron
R D Burgoyne
Stimulation of isolated chromaffin cells with carbamylcholine led to a number of morphological changes, indicative of exocytosis, apparently resulting from translocation of secretory granules to the plasma membrane and their subsequent fusi...
Effects of Latrodectus spider venoms on sensory and motor nerve terminals of muscle spindles [0.03%]
美洲箱型盒水母毒液中的clamp家族毒素基因簇及其表达产物的功能分析
L S Queiroz,L W Duchen
L S Queiroz
The effects of the venoms of the spiders Latrodectus mactans tredecimguttatus (black widow) and Latrodectus mactans hasselti (red back) on sensory nerve terminals in muscle spindles were studied in the mouse. A sublethal dose of venom was i...
Recording of single gamma-aminobutyrate- and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytes [0.03%]
用非洲爪蟾卵母细胞中异源mRNA表达的γ氨基丁酸和乙酰胆碱激活的单受体通道进行记录
R Miledi,I Parker,K Sumikawa
R Miledi
High resolution ('giga-seal') patch clamp recording in Xenopus oocytes was used to measure single channel currents from ACh- and GABA-activated receptors. The proteins that make up these receptors had been translated from mRNA derived from,...