Stefanie-Elisabeth Heumüller,Ina Maja Vorberg
Stefanie-Elisabeth Heumüller
Neurodegenerative diseases are associated with misfolding of proteins into highly-ordered amyloid fibrils. These protein aggregates can be transmitted to other cells in which they induce aggregation of proteins of the same kind. Mechanisms ...
Martin Pilhofer,Jochen Graw,Henning Hintzsche
Martin Pilhofer
Christian Sigl,Hendrik Dietz
Christian Sigl
The current pandemic has highlighted the need for new antiviral therapies, to respond to existing and emerging diseases transmitted by viral vectors. We developed a novel antiviral approach that is based on neutralizing viruses by trapping ...
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Sven Krappmann,Johannes Sander,Ivan Berg et al.
Sven Krappmann et al.
Anika Nolte,Oleg Pak,Natascha Sommer
Anika Nolte
Adaptation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation. Acute oxygen sensing thus is a fundamental pre-requisi...
Esther Veronika Wenzel,Kilian Johannes Carl Zilkens
Esther Veronika Wenzel
Despite readily available alternative technologies, many antibodies in research and diagnostics are still generated and produced with the use of laboratory animals. Here, we portrait the concept of animal-free recombinant antibodies and the...
Michael Schloter,Daniela Kruck,Henning Hintzsche
Michael Schloter
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Andreas Peschel,Andreas Diepold,Thilo M Fuchs et al.
Andreas Peschel et al.
Ralf Bartenschlager
Ralf Bartenschlager
The severe acute respiratory syndrome Coronavirus type 2 (SARS-CoV-2) has caused a pandemic with major impact on human society, the economy, and our daily life. SARS-CoV-2 is a plus-strand RNA virus causing death of infected cells and an in...
Doris Wilflingseder,Wilfried Posch
Doris Wilflingseder
Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe SARS-CoV-2 infection and is associated with enhanced pathogenicity and mortality. Complement hyper activation promotes lung injury and was observed...