Weng Kee Wong,Yue Yin,Julie Zhou
Weng Kee Wong
We introduce a powerful and yet seldom used numerical approach in statistics for solving a broad class of optimization problems where the search space is discretized. This optimization tool is widely used in engineering for solving semidefi...
Lukas Koelbl,Manfred Deistler
Lukas Koelbl
In this paper we present a new estimation procedure named MF-IVL for VAR systems in the case of mixed-frequency data, where the data maybe, e.g., stock or flow data. The main idea of this new procedure is to project the slow components on t...
Asymptotic properties of maximum likelihood estimators with sample size recalculation [0.03%]
样本量重估算时最大似然估计的渐近性质研究
Sergey Tarima,Nancy Flournoy
Sergey Tarima
Consider an experiment in which the primary objective is to determine the significance of a treatment effect at a predetermined type I error and statistical power. Assume that the sample size required to maintain these type I error and powe...
A web-based tool for designing experimental studies to detect hormesis and estimate the threshold dose [0.03%]
一种基于网络的工具，用于设计检测低剂量增强效应并估计阈值剂量的实验研究
Víctor Casero-Alonso,Andrey Pepelyshev,Weng K Wong
Víctor Casero-Alonso
Hormesis has been widely observed and debated in a variety of context in biomedicine and toxicological sciences. Detecting its presence can be an important problem with wide ranging implications. However, there is little work on constructin...
Incoherent dose-escalation in phase I trials using the escalation with overdose control approach [0.03%]
基于剂量限值的I期爬坡试验中剂量跳跃导致的累积给药强度不一致问题
Graham M Wheeler
Graham M Wheeler
A desirable property of any dose-escalation strategy for phase I oncology trials is coherence: if the previous patient experienced a toxicity, a higher dose is not recommended for the next patient; similarly, if the previous patient did not...
Inference on the marginal distribution of clustered data with informative cluster size [0.03%]
具有信息量的群大小的聚类数据边际分布的推断
Jaakko Nevalainen,Somnath Datta,Hannu Oja
Jaakko Nevalainen
In spite of recent contributions to the literature, informative cluster size settings are not well known and understood. In this paper, we give a formal definition of the problem and describe it from different viewpoints. Data generating me...