Overexpression of choline acetyltransferase reconstitutes discrete acetylcholine release in some but not all synapse formation-defective neuroblastoma cells [0.03%]
胆碱乙酰转移酶的过度表达部分恢复了某些但并非所有突触形成缺陷神经母细胞瘤细胞中的乙酰胆碱的局部释放
Z G Zhong,H Misawa,S Furuya et al.
Z G Zhong et al.
Secretion of acetylcholine (ACh) in neuroblastoma cells overexpressing choline acetyltransferase (ChAT) was examined. With transient transfection of ChAT cDNA, neuroblastoma cells, which have no endogenous ChAT and either adhere to myotubes...
A Vincent,M Roberts,H Willison et al.
A Vincent et al.
Myasthenia gravis, the Lambert-Eaton myasthenic syndrome, and acquired neuromyotonia are three disorders of the neuromuscular junction or motor nerve that are caused by autoantibodies to ion channel proteins: acetylcholine receptors, voltag...
Inositol trisphosphate and cyclic ADP ribose as long range messengers generating local subcellular calcium signals [0.03%]
肌醇三磷酸和环ADP核糖作为远程信使生成局部细胞内钙信号
O H Petersen
O H Petersen
The process of messenger-mediated release of Ca2+ from intracellular stores, which is of great importance in virtually all cell types including neurons, can best be studied in cells lacking voltage-gated Ca2+ channels in the plasma membrane...
P Drapeau,S Catarsi,D C Merz
P Drapeau
We have investigated the signals between identified leech neurons during the formation of specific synapses in culture. At an inhibitory serotonergic synapse between two well-studied neurons, the postsynaptic cell has an additional (extrasy...
M Matteoli,C Verderio,K Krawzeski et al.
M Matteoli et al.
To improve our understanding of the mechanisms which regulate the formation and the functional maturation of synaptic contacts between neurons, we used hippocampal neurons maintained in primary cultures as experimental system. In this model...
O Rossetto,F Deloye,B Poulain et al.
O Rossetto et al.
Tetanus and botulinum neurotoxins are produced by several Clostridia and cause the paralytic syndromes of tetanus and botulism by blocking neurotransmitter release at central and peripheral synapses, respectively. They consist of two disulf...
Long-term regulation of short-term plasticity: a postsynaptic influence on presynaptic transmitter release [0.03%]
长期调控短期可塑性：突触后对突触前递质释放的影响
G W Davis
G W Davis
The dynamics of presynaptic transmitter release are often matched to the physiological properties and function of the postsynaptic cell. Evidence in organisms as diverse as the cricket central nervous system and the cat spinal cord suggests...
Using paired-pulse facilitation to probe the mechanisms for long-term potentiation (LTP) [0.03%]
利用配对脉冲增强探讨长期增益的机制(LTP)
P E Schulz,E P Cook,D Johnston
P E Schulz
Paired-pulse facilitation (PPF) of excitatory synaptic transmission at Schaffer collateral synapses in the hippocampus was examined in relationship to long-term potentiation (LTP). PPF is a relatively simple-to-measure presynaptic form of s...
J Midtgaard
J Midtgaard
Synaptic integration occurs within a framework of synaptic connections, and cell type-specific, intrinsic and transmitter-gated ion channels. These components are differentially distributed over the somato-dendritic membrane. Recent results...
Neurotrophin-induced modulation of synaptic transmission in the adult hippocampus [0.03%]
神经营养因子诱导的成人海马突触传递的调节
H J Kang,E M Schuman
H J Kang
The NGF-family of neurotrophic factors including NGF, BDNF and NT-3,4/5 is known to be crucial for neuronal survival and differentiation during development. However, recent studies suggest that the neurotrophins are also widely expressed an...