A F Oberhauser,I M Robinson,J M Fernandez
A F Oberhauser
We measured the exocytotic response induced by a rapid and global increase in the concentration of Ca2+ or GTP gamma S (achieved by flash photolysis of caged compounds) in mast cells and chromaffin cells. Secretion was measured by following...
Genetic dissection of the molecular mechanisms of transmitter vesicle release during synaptic transmission [0.03%]
遗传学解剖突触传递中递质囊泡释放的分子机制
K S Broadie
K S Broadie
Over the last few years there has been rapid progress in our understanding of the molecular mechanisms of synaptic transmission. This advance is largely due to the convergence of biochemical and genetic approaches to identify a discrete set...
The effect of calcium levels on synaptic proteins. A study on VAT-1 from Torpedo [0.03%]
钙浓度对突触蛋白的影响：Torpedo的VAT-1研究
M Linial,O Levius,N Ilouz et al.
M Linial et al.
In this study we compare major synaptic proteins from Torpedo electric organ to their homologues from mammalian brain. Most of these proteins are members of small gene families. We demonstrate a high degree of evolutionary conservation of m...
H Kilbinger,C Dietrich,R S von Bardeleben
H Kilbinger
Pre- and postsynaptic muscarinic receptors have been characterized in the isolated trachea and ileal circular muscle of the guinea pig. The muscarinic autoreceptors mediating inhibition of acetylcholine release in the circular muscle belong...
Fluorescence approaches to the study of the actin-nucleating and bundling activities of synapsin I [0.03%]
荧光研究法研究突触蛋白I的肌动蛋白核化及聚束活性
F Valtorta,P E Ceccaldi,F Grohovaz et al.
F Valtorta et al.
Synapsin I is a neuron-specific phosphoprotein which binds to small synaptic vesicles and actin in a phosphorylation-dependent fashion. We have analyzed the ability of synapsin I to interact with actin monomers and filaments using purified ...
Analysis of the structure and expression of the VAMP family of synaptic vesicle proteins [0.03%]
泛素化囊泡蛋白VAMP家族的结构与表达分析
W S Trimble
W S Trimble
VAMP/synaptobrevin proteins were first discovered as small integral membrane proteins in synaptic vesicles of vertebrates and invertebrates. At least two isoforms are expressed in the central nervous system of mammals in non-overlapping pat...
Lack of involvement of [Ca2+]i in the external Ca(2+)-independent release of acetylcholine evoked by veratridine, ouabain and alpha-latrotoxin: possible role of [Na+]i [0.03%]
Veratridine、哇巴因及_alpha-神经毒素_引起的乙酰胆碱非钙依赖性释放与细胞内Ca2+无关但与细胞内Na+有关的可能性
V Adam-Vizi,Z Deri,P Bors et al.
V Adam-Vizi et al.
Synaptosomes were challenged by veratridine, ouabain and alpha-latrotoxin, and the release of 14C-acetylcholine (ACh) was measured in the absence of external Ca2+. We wished to test whether Ca2+ mobilized from internal stores triggered the ...
Synaptotagmin: a Lambert-Eaton myasthenic syndrome antigen that associates with presynaptic calcium channels [0.03%]
突触素：与末梢钙通道相联系的郎伯-伊顿综合征抗原
N Martin-Moutot,O el Far,C Leveque et al.
N Martin-Moutot et al.
Plasma from patients with Lambert-Eaton myasthenic syndrome (LEMS), an autoimmune disease of neuromuscular transmission, contains antibodies that immunoprecipitate 125I-omega-conotoxin GVIA labeled-calcium channels solubilized from rat brai...
Changes of gastric mucosal biochemistry in ethanol-treated rats with and without acute surgical vagotomy [0.03%]
乙醇处理的大鼠迷走神经切断术前后的胃粘膜生化变化
A Vincze,A Király,G Sütö et al.
A Vincze et al.
The biochemical background of ethanol-(ETOH) induced gastric mucosal damage was studied in rats with intact vagus and after acute surgical vagotomy. Observations were carried out on Sprague-Dawley (CFY) strain rats of both sexes. Gastric mu...
Gastric lesion development in normal and pylorus ligated rats after cervical vagotomy [0.03%]
颈部迷走神经切断术后正常及幽门结扎大鼠胃粘膜病变的发展过程研究
V Corić,J Culig,I Zoricić et al.
V Corić et al.
The main purpose of this study was to further investigate the effects of vagotomy on gastric lesion development. In contrast to the usual subdiaphragmal vagotomy, a different vagotomy at the level of the trigonum caroticum was used both alo...