E Kostenis,F Y Zeng,J Wess
E Kostenis
The structural basis underlying the G protein coupling selectivity of different muscarinic receptor subtypes was analyzed by using a combined molecular genetic/biochemical approach. These studies led to the identification of key residues on...
Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter [0.03%]
毒蕈碱型乙酰胆碱受体激活乙酰胆碱酯酶基因启动子
R M Nitsch,S Rossner,C Albrecht et al.
R M Nitsch et al.
The acetylcholinesterase (AChE) gene promoter contains several overlapping binding sites for Sp1 and Egr-1 transcription factors. Cotransfection experiments and promoter assays showed that Egr-1 can potently activate transcription from the ...
Position effect variegations and brain-specific silencing in transgenic mice overexpressing human acetylcholinesterase variants [0.03%]
人乙酰胆碱酯酶变异型转基因小鼠中的基因座效应花斑现象及大脑特异性沉默作用
M Sternfeld,J D Patrick,H Soreq
M Sternfeld
Position effect variegations as well as brain-specific silencing were observed in novel transgenic mouse pedigrees expressing human acetylcholinesterase (AChE) variants. Muscle AChE activities varied between 1.6- and 350-fold of control in ...
J M Matter,L Matter-Sadzinski,T Roztocil et al.
J M Matter et al.
The promoters driving transcription of the neuronal nicotinic genes alpha 7 and beta 3 have been characterized in the chicken. Although their regulatory modalities are thoroughly different, they nevertheless lead to co-expression in the sam...
Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors [0.03%]
别构调节剂对胆碱能受体的作用及功能的影响
S Tucek,J Jakubík,V Dolezal et al.
S Tucek et al.
Data are reviewed indicating that allosteric modulators can enhance the affinities of muscarinic receptors for their antagonists and agonists, that the enhancement of the affinity for agonists is relevant functionally, and that the alloster...
K Löffelholz
K Löffelholz
Choline is product and precursor to both acetylcholine and membrane phospholipids, and, in the brain, is ultimately provided by the circulation. The brain is protected from excess choline and choline deprivation by a refined system of homeo...
M Shoaib
M Shoaib
Nicotine, like other drugs when abused, can produce a wide array of behaviours, some of which collectively propel 'drug-seeking behaviour'. This review focuses on three stimulus properties of nicotine and examines the role of dopamine in me...
Neural substrate of nicotine addiction as defined by functional brain maps of gene expression [0.03%]
尼古丁成瘾功能基因表达图谱定义的神经基础
E M Pich,C Chiamulera,M Tessari
E M Pich
The distributed neural networks involved in the intravenous self-administration of nicotine and cocaine, and in a model of relapse of nicotine-taking after abstinence, were compared in Wistar rats. Post-mortem brain maps of c-fos-related an...
The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594 [0.03%]
神经尼古丁乙酰胆碱受体在止痛中的作用：ABT-594的影响
M W Decker,P Curzon,M W Holladay et al.
M W Decker et al.
ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive i...
The hypothesis of an ambient level of acetylcholine in the central nervous system [0.03%]
中枢神经系统乙酰胆碱基础水平假说
L Descarries
L Descarries
Recent ultrastructural data demonstrate the largely asynaptic character of the cholinergic innervation in many regions of adult rat brain. These data favour the hypothesis of a diffuse transmission/modulation by acetylcholine in the CNS and...