Determination of Helicobacter pylori cagA, vacA genotypes with real-time PCR melting curve analysis [0.03%]
应用实时PCR熔解曲线分析方法检测幽门螺杆菌毒力基因cagA、vacA型别研究
A Ruzsovics,B Molnar,Z Unger et al.
A Ruzsovics et al.
Objectives: genotypes of Helicobacter pylori are the focus of interest because they play a prominent role in mucosal injury. The purpose of this study was to determine cagA and vacA genotypes of H. pylori using real-time ...
Epidermal growth factor and prostaglandin E(2) accelerate mucosal recovery from stress-induced gastric lesions via inhibition of apoptosis [0.03%]
表皮生长因子和前列腺素E2通过抑制细胞凋亡加速应激性胃黏膜溃疡愈合
P C Konturek,T Brzozowski,A Duda et al.
P C Konturek et al.
The repair of damaged gastric mucosa is a complex process involving prostaglandins (PG) and mucosal growth factors such as epidermal growth factor (EGF). Recently, we postulated that the increased occurrence of apoptosis in the gastric epit...
Effect of Helicobacter pylori infection and eradication on gastric epithelial cell proliferation and apoptosis [0.03%]
幽门螺杆菌感染及根除与胃上皮细胞增殖和凋亡的关系研究
Z Unger,B Molnár,E Szaleczky et al.
Z Unger et al.
Objectives: the effect of Helicobacter pylori infection on gastric epithelial cell proliferation and apoptosis is still controversial. Our aim was to evaluate the effect of H. pylori infection on cell kinetic parameters i...
P C Konturek,S J Konturek,T Brzozowski et al.
P C Konturek et al.
Leptin, a 16 kDa protein encoded by the ob gene, is known mainly for its role in the regulation of food intake, body composition and energy expenditure through a central feedback mechanism. Initially leptin was considered as an ob gene prod...
Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways [0.03%]
胃溃疡愈合期间胃粘膜再生由生长因子和信号转导通路引发
A Tarnawski,I L Szabo,S S Husain et al.
A Tarnawski et al.
An ulcer is a deep necrotic lesion penetrating through the entire thickness of the gastrointestinal mucosa and muscularis mucosae. Ulcer healing is a complex and tightly regulated process of filling the mucosal defect with proliferating and...
Gene expression and gene therapy in experimental duodenal ulceration [0.03%]
基因表达及基因治疗在实验性十二指肠溃疡中的作用
S Szabo,X Deng,T Khomenko et al.
S Szabo et al.
Gastroduodenal ulceration is still poorly understood and changes in gene expression may provide new mechanistic insights. Previously, we demonstrated that angiogenic growth factors are potent ulcer healing agents, and the synthesis of bFGF,...
Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine [0.03%]
稳定胃十五肽BPC 157（PL-10，PLD-116）和普萘洛尔可预防和逆转慢性饮酒大鼠门脉高压及肝病，而雷尼替丁则不能
I Prkacin,J Separovic,G Aralicia et al.
I Prkacin et al.
Liver lesions and portal hypertension in rats, following chronic alcohol administration, are a particular target for therapy. Portal hypertension (mm Hg) assessed directly into the portal vein, and liver lesions induced by 7.28 g/kg b.w. of...
Phytohaemagglutinin inhibits gastric acid but not pepsin secretion in conscious rats [0.03%]
红血球凝集素抑制清醒大鼠胃酸但不抑制胃蛋白酶的分泌
K Kordás,G Szalmay,S Bardocz et al.
K Kordás et al.
Phytohaemagglutinin (PHA), a kidney bean lectin, is known for its binding capability to the small intestinal surface. There has been no data available, however, on the biological activity of PHA in the stomach. Recent observations indicate ...
Lung lesions and anti-ulcer agents beneficial effect: anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats [0.03%]
胃溃疡药物对肺部病灶的有益影响：十五肽BPC 157、法莫替丁、奥美拉唑和阿托品改善大鼠肺损伤
D Stancic-Rokotov,Z Slobodnjak,J Aralica et al.
D Stancic-Rokotov et al.
Anti-ulcer agents may likely attenuate lesions outside the gastrointestinal tract, since they had protected gastrectomized rats (a "direct cytoprotective effect"). Therefore, their therapeutic potential in lung/stomach lesions were shown. R...
Chronic cytoprotection: pentadecapeptide BPC 157, ranitidine and propranolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats [0.03%]
长效细胞保护作用：十五肽BPC 157、雷尼替丁和心得安预防、减轻及逆转长期饮酒大鼠胃部病变
I Prkacin,G Aralica,D Perovic et al.
I Prkacin et al.
Unlike severe gastric damage acutely induced by ethanol administration in rat, the ulcerogenic effect of chronic alcohol administration (3.03 g/kg b.w. or 7.28 g/kg b.w.) given in drinking water, producing liver lesions and portal hypertens...