Natalia Denisenko-Nehrbass,Catherine Faivre-Sarrailh,Laurence Goutebroze et al.
Natalia Denisenko-Nehrbass et al.
The axoglial paranodal junctions, flanking the Ranvier nodes, are specialized adhesion sites between the axolemma and myelinating glial cells. Unraveling the molecular composition of paranodal junctions is crucial for understanding the mech...
Kim T Nguyen-Ba-Charvet,Alain Chédotal
Kim T Nguyen-Ba-Charvet
Diffusible chemorepellents play a major role in guiding developing axons towards their correct targets by preventing them from entering or steering them away from certain regions. Genetic studies in Drosophila revealed a novel repulsive gui...
Angela Gritti,Angelo L Vescovi,Rossella Galli
Angela Gritti
Stem cells play an essential role during the processes of embryonic tissue formation and development and in the maintenance of tissue integrity and renewal throughout adulthood. The differentiation potential of stem cells in adult tissues h...
Activity-dependent neuronal differentiation prior to synapse formation: the functions of calcium transients [0.03%]
细胞连接形成之前的活动依赖性神经元分化：钙离子瞬变的功能
Nicholas C Spitzer
Nicholas C Spitzer
Spinal cord neurons become excitable prior to synapse formation, and generate spontaneous calcium transients that regulate aspects of their differentiation before neuronal networks are established. Calcium spikes, generated by calcium-depen...
Xavier Castell,Marie Françoise Diebler,Monique Tomasi et al.
Xavier Castell et al.
Expression of choline acetyltransferase (ChAT) and of the vesicular acetylcholine transporter (VAChT) is required for the acquisition and the maintenance of the cholinergic phenotype. The ChAT and VAChT genes have been demonstrated to share...
Upregulation of acetylcholine synthesis by bone morphogenetic protein 9 in a murine septal cell line [0.03%]
骨形态生成蛋白9通过一组色氨酸依赖的步骤上调基底前脑胆碱能神经元乙酰胆碱合成能力
Ignacio López-Coviella,Brygida Berse,R Scott Thies et al.
Ignacio López-Coviella et al.
Previous studies showed that bone morphogenetic protein 9 (BMP-9) induces the expression of choline acetyltransferase and the vesicular acetylcholine (ACh) transporter, and upregulates ACh synthesis in cultured primary neurons from embryoni...
Emmanuel Chaubourt,Vincent Voisin,Philippe Fossier et al.
Emmanuel Chaubourt et al.
Duchenne muscular dystrophy (DMD), the severe X-linked recessive disorder which results in progressive muscle degeneration, is due to a lack of dystrophin, a membrane cytoskeletal protein. Three types of treatment are envisaged: pharmacolog...
Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy [0.03%]
调控骨骼肌纤维中utrophin表达和定位的多种调节事件：杜氏肌营养不良症治疗策略的新见解
Bernard J Jasmin,Lindsay M Angus,Guy Bélanger et al.
Bernard J Jasmin et al.
Duchenne muscular dystrophy (DMD) is the most prevalent inherited muscle disease and results from mutations/deletions in the X-linked dystrophin gene. Although several approaches have been envisaged to counteract the effects of this progres...
Kerstin Krieglstein,Jens Strelau,Andreas Schober et al.
Kerstin Krieglstein et al.
Transforming growth factor-betas (TGF-betas) constitute a superfamily of multifunctional cytokines with important implications in morphogenesis, cell differentiation, and tissue remodeling. In the developing nervous system, TGF-beta2 and -b...
Rhona Mirsky,Kristjan R Jessen,Angela Brennan et al.
Rhona Mirsky et al.
Myelinating and non-myelinating Schwann cells of peripheral nerves are derived from the neural crest via an intermediate cell type, the Schwann cell precursor [K.R. Jessen, A. Brennan, L. Morgan, R. Mirsky, A. Kent, Y. Hashimoto, J. Gavrilo...