Andreas Otte,Ulrike Halsband
Andreas Otte
In this chapter brain imaging tools in neurosciences are presented. These include a brief overview on single-photon emission tomography (SPET) and a detailed focus on positron emission tomography (PET) and functional magnetic resonance imag...
Polyamine and aminoguanidine treatments to promote structural and functional recovery in the adult mammalian brain after injury: a brief literature review and preliminary data about their combined administration [0.03%]
多胺和氨基胍治疗促进成人哺乳动物脑损伤后的结构和功能恢复：文献综述及联合应用的初步数据
Sarah Schimchowitsch,Jean-Christophe Cassel
Sarah Schimchowitsch
The regeneration potential of the adult mammalian central nervous system (CNS) is very modest, due to, among other factors, the presence of either a glial scar, or myelin-associated regeneration inhibitors such as Nogo-A, MAG and OMgp, whic...
Neuronal dysfunction in Down syndrome: contribution of neuronal models in cell culture [0.03%]
唐氏综合症神经元功能障碍：细胞培养中神经元模型的贡献
Katherine Saud,Christian Arriagada,Ana María Cárdenas et al.
Katherine Saud et al.
Down syndrome (DS) in humans, or trisomy of autosome 21, represents the hyperdiploidy that most frequently survives gestation, reaching an incidence of 1 in 700 live births. The condition is associated with multisystemic anomalies, includin...
Glutamate release from astrocytes as a non-synaptic mechanism for neuronal synchronization in the hippocampus [0.03%]
胶质细胞释放谷氨酸作为海马神经同步的非突触机制
Giorgio Carmignoto,Tommaso Fellin
Giorgio Carmignoto
Synchronization of activity of anatomically distributed groups of neurons represents a fundamental event in the processing of information in the brain. While this phenomenon is believed to result from dynamic interactions within the neurona...
Marion Benoist,Stéphane Gaillard,Francis Castets
Marion Benoist
Proteins of the striatin family have been identified in all multicellular animals. They are multidomain molecules containing several protein-interacting motifs. In mammals, these proteins are principally expressed in neurons with a somato-d...
Michal Slezak,Frank W Pfrieger,Zbigniew Soltys
Michal Slezak
Recent discoveries suggest that astrocytes are an integral part of synaptic connections, as they sense and modulate synaptic activity. Moreover, there is evidence that astrocytes change the number of synaptic connections directly via synapt...
Didier Rognan
Didier Rognan
The concomitant development of in silico screening technologies and of three-dimensional information on therapeutically relevant macromolecular targets makes it possible to navigate in the structural proteome and to identify targets fulfill...
Gorazd B Stokin,Lawrence S B Goldstein
Gorazd B Stokin
It is currently thought that Alzheimer's disease develops due to aberrant generation of amyloid-beta peptides. However, the mechanisms underlying the aberrant generation of amyloid-beta peptides remain unknown. An emerging concept suggests ...
Stéphanie Bezin,Gilles Charpentier,Philippe Fossier et al.
Stéphanie Bezin et al.
Many physiological processes are controlled by a great diversity of Ca2+ signals. Within cell, Ca2+ signals depend upon Ca2+ entry and/or Ca2+ release from internal Ca2+ stores. The control of Ca2+-store mobilization is ensured by a family ...
Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity? [0.03%]
尼古丁通过改善细胞内神经递质烟碱受体的成熟来增强神经可塑性吗？
Pierre-Jean Corringer,Jérôme Sallette,Jean-Pierre Changeux
Pierre-Jean Corringer
Nicotine addiction, the primary cause of tobacco consumption, is mediated through nicotine binding to brain nicotinic acetylcholine receptor (nAChRs). Upon chronic exposure, nicotine elicits a cascade of events, starting with nAChR activati...