The role of pharmacists in the recruitment of a cohort for postmarketing surveillance. A case study of acitretin in The Netherlands [0.03%]
药师在药品上市后再评价中的作用-以荷兰的阿维A酯为例
M C Sturkenboom,B H Stricker,L T de Jong-van den Berg et al.
M C Sturkenboom et al.
In October 1990, a recall procedure was issued regarding the drug acitretin. The recommended post-therapy contraception period after acitretin therapy was extended from 2 months to 2 years. For a postmarketing surveillance study, we recruit...
J Bron,G J Sterk,J F van der Werf et al.
J Bron et al.
New organic nitrate esters, derived from structurally different (cyclo)aliphatic templates, were synthesized and pharmacologically investigated. Their in vitro vascular smooth muscle relaxing activities and, occasionally, in vivo haemodynam...
Biosynthesis of pseudoisoeugenols in tissue cultures of Pimpinella anisum. Phenylalanine ammonia lyase and cinnamic acid 4-hydroxylase activities [0.03%]
当归子组织培养中伪异丁香酚的生物合成：苯氨酶和桂皮酸4-羟化酶活性
J Reichling,B Kemmerer,H Sauer-Gürth
J Reichling
The genus Pimpinella contains pseudoisoeugenols, phenylpropanoids with a rare 2,5-dioxy substitution pattern on the phenyl ring. To study the biosynthesis of these compounds, we set up a leaf-differentiating tissue culture of Pimpinella ani...
Y P Zhu,H J Woerdenbag
Y P Zhu
Herbal medicine, acupuncture and moxibustion, and massage are the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the most important part ...
Stability of bupivacaine hydrochloride with diamorphine hydrochloride in an epidural infusion [0.03%]
盐酸布比卡因与盐酸二氢吗啡酮腰麻注药液的稳定性研究
A R Barnes,S Nash
A R Barnes
The stability of diamorphine (0.02 mg/ml as the hydrochloride) in 250 ml bupivacaine hydrochloride (0.15% wt/vol infusion) was studied by high pressure liquid chromatography at temperatures in the range 7 to 45 degrees C. Diamorphine hydroc...
J Vlcek,M Tesarová,Z Fendrich
J Vlcek
In the present pilot study an attempt was made to evaluate the usefulness of results obtained about the treatment of patients suffering from high blood pressure for a pharmacoepidemiological study of the therapeutic value of antihypertensiv...
Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs [0.03%]
含双封闭巯基的乐多辛清除活性氧类研究及其与含有游离巯基药物比较
B Gressier,N Lebegue,C Brunet et al.
B Gressier et al.
Acute production of reactive oxygen species by polymorphonuclear neutrophils during the respiratory burst may induce tissue injuries. In this in vitro study, it was demonstrated that letosteine, a mucolytic agent containing two blocked thio...
J Dingemanse
J Dingemanse
Insomnia is a complex complaint which is often multifactorial in origin. Pharmacotherapy can only be an adjunct in the treatment of insomnia and hypnotics should be given on an intermittent basis for short periods of time. An overview is pr...
A L Wertheimer,K B Andrews
A L Wertheimer
Pharmacoepidemiology is the application of epidemiological principles and methods to the study of drug effects in human populations. The goal of this discipline is to characterize, control and predict the effects and uses of pharmacological...
New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase [0.03%]
治疗实体瘤的嘧啶反代谢物新靶点。1:胸苷酸合成酶
C L van der Wilt,G J Peters
C L van der Wilt
Thymidylate synthase forms the target for anticancer therapy with fluoropyrimidines. Anticancer activity can be increased by the use of different modulators of fluoropyrimidine metabolism, which lead to an enhanced inhibition of thymidylate...