Brain tissue oxygen pressure monitoring in awake patients during functional neurosurgery: the assessment of normal values [0.03%]
清醒功能神经外科患者的脑组织氧压监测及正常值评估
Frederik A Pennings,P Richard Schuurman,Pepijn van den Munckhof et al.
Frederik A Pennings et al.
Local brain tissue oxygen (ptiO2) monitoring is frequently applied in patients at risk for cerebral ischemia. To identify ischemic thresholds, the normal range of local brain tissue oxygen pressure (ptiO2) values needs to be established. Id...
CYP4Fs expression in rat brain correlates with changes in LTB4 levels after traumatic brain injury [0.03%]
大鼠脑损伤后CYP4F表达与LTB4水平变化相关性研究
Ying Wang,Jing Zhao,Auinash Kalsotra et al.
Ying Wang et al.
Cytochrome P450 (CYP) 4Fs constitute a subgroup of the cytochrome P450 superfamily and are involved in cellular protection and metabolism of numerous molecules, including drugs, toxins, and eicosanoids. CYP4Fs are widely distributed in rat ...
Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats [0.03%]
在大鼠创伤性脑损伤期间阻断细胞内钠离子和钙离子内流对海马的不同保护作用
Xueren Zhao,Fredric A Gorin,Robert F Berman et al.
Xueren Zhao et al.
This study investigated the contributions of the reverse mode of the sodium-calcium exchanger (NCX) and the type 1 sodium-proton antiporter (NHE-1) to acute astrocyte and neuronal pathology in the hippocampus following fluid percussion trau...
Traumatic brain injury research priorities: the Conemaugh International Brain Injury Symposium [0.03%]
原发性脑外伤的研究重点-Conemaugh国际脑损伤研讨会
George A Zitnay,Kevin M Zitnay,John T Povlishock et al.
George A Zitnay et al.
In 2005, an international symposium was convened with over 100 neuroscientists from 13 countries and major research centers to review current research in traumatic brain injury (TBI) and develop a consensus document on research issues and p...
Diffusion-weighted imaging improves outcome prediction in pediatric traumatic brain injury [0.03%]
弥散张量成像可改善儿童创伤性脑损伤的预后评估
Nicholas R Galloway,Karen A Tong,Stephen Ashwal et al.
Nicholas R Galloway et al.
Diffusion-weighted imaging (DWI) and consequent apparent diffusion coefficient (ADC) maps have been used for lesion detection and as a predictor of outcome in adults with traumatic brain injury (TBI), but few studies have been reported in c...
Characterization of the pharmacokinetics of human recombinant erythropoietin in blood and brain when administered immediately after lateral fluid percussion brain injury and its pharmacodynamic effects on IL-1beta and MIP-2 in rats [0.03%]
人重组促红细胞生成素在液态撞击脑损伤后给药时在血液和大脑中的药代动力学特征及其对大鼠IL-1β和MIP-2的药理动力学效应的表征研究
Thomas Lieutaud,Peter J D Andrews,Jonathan K J Rhodes et al.
Thomas Lieutaud et al.
This study sought to determine the bio-availability of recombinant human erythropoietin (EPO) in the brain and blood and its effects on the cerebral concentrations of the inflammatory mediators interleukin-1beta (IL-1beta) and macrophage-in...
Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation [0.03%]
雌激素通过磷脂酰肌醇-3-激酶/Akt依赖的CREM激活诱导脊髓损伤后Bcl-2表达
Tae Y Yune,Hong G Park,Jee Y Lee et al.
Tae Y Yune et al.
Our previous study showed that, after spinal cord injury (SCI) in rats, estrogen provides neuroprotection through expression of Bcl-2. However, molecular targets that mediate estrogen-induced expression of Bcl-2 are not fully understood. He...
Acute subdural hematoma in pigs: role of volume on multiparametric neuromonitoring and histology [0.03%]
猪急性硬膜下血肿的体积对多参数神经监测和组织学的影响
Ralph Timaru-Kast,Anke Meissner,Axel Heimann et al.
Ralph Timaru-Kast et al.
Traumatic brain injury (TBI) is often complicated by acute subdural hemorrhage (ASDH) with a high mortality rate. The pathophysiological mechanisms behind such an injury type and the contribution of blood to the extent of an injury remain p...
Magnetic resonance imaging detects and predicts early brain injury after subarachnoid hemorrhage in a canine experimental model [0.03%]
磁共振成像是犬子动脉瘤性蛛网膜下腔出血(subarachnoid hemorrhage)后早期脑损伤的检测和预测方法
Vikram Jadhav,Takashi Sugawara,John Zhang et al.
Vikram Jadhav et al.
The canine double hemorrhage model is an established model to study cerebral vasospasm, the late sequelae of subarachnoid hemorrhage (SAH). The present study uses magnetic resonance imaging (MRI) to examine the recently reported early brain...
The phosphorylated axonal form of the neurofilament subunit NF-H (pNF-H) as a blood biomarker of traumatic brain injury [0.03%]
神经丝H亚基磷酸化形式(pNF-H)作为创伤性脑损伤的血液生物标志物
Kevin J Anderson,Stephen W Scheff,Kelly M Miller et al.
Kevin J Anderson et al.
The detection of neuron-specific proteins in blood might allow quantification of the degree of neuropathology in experimental and clinical contexts. We have been studying a novel blood biomarker of axonal injury, the heavily phosphorylated ...