Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line [0.03%]
纳米炭黑诱发的DNA损伤在人肺癌上皮A549细胞系中导致生长停止和AP-1及NFkappaB的DNA结合力增强
R M Mroz,R P F Schins,H Li et al.
R M Mroz et al.
To assess whether nanoparticle (NP) driven DNA damage induces the expression of proinflammatory transcription factors such as NFB and AP-1 A549, lung epithelial cells were treated with Carbon Black (CB), nanoparticulate CB (NPCB), NPCB coat...
Molecular basis of chronic inflammation in lung diseases: new therapeutic approach [0.03%]
慢性肺部疾病炎症的分子机制及新的治疗策略
R M Mroz,J Noparlik,E Chyczewska et al.
R M Mroz et al.
There is increasing evidence that histone acetylation, controlled by histone acetyltransferases (HAT), reversed by histone deacetylases (HDAC) plays a critical role in the process of regulation of inflammatory genes and in mediating the ant...
Comparison of induced sputum and bronchoalveolar lavage fluid cell profile during the treatment of pulmonary sarcoidosis [0.03%]
诱导痰液和支气管肺泡灌洗液细胞谱系在治疗肺结节病中的比较研究
R M Mroz,M Korniluk,A Stasiak-Barmuta et al.
R M Mroz et al.
In this study we compared the cellular profiles of induced sputum (IS) and BAL in newly diagnosed sarcoidosis patients before and after 6 months of prednisone therapy. The study encompassed 17 untreated patients with stage II pulmonary sarc...
Cytoplasm-nuclear trafficking of CREB and CREB phosphorylation at Ser133 during therapy of chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的治疗过程中CREB的胞核-胞浆转运及Ser133磷酸化
R M Mroz,A Holownia,E Chyczewska et al.
R M Mroz et al.
cAMP responsive element binding protein (CREB) plays an important role in transcriptional machinery. CREB signaling is altered in patients with asthma. However, the role of CREB in chronic obstructive pulmonary disease (COPD) is less clear....
Body balance in patients with systemic vertigo after rehabilitation exercise [0.03%]
系统性眩晕患者的康复训练后身体平衡状况改善
M Mraz,M Curzytek,M A Mraz et al.
M Mraz et al.
The aim of this paper was to characterize structural balance of the body in people with systemic vertigo after applying rehabilitation exercise, such as motor-visual coordination on a posturographic platform and balance exercise. Physiother...
Evaluation of the cough reflex and airway reactivity in toluene- and ovalbumin-induced airway hyperresponsiveness [0.03%]
评估甲苯和卵清蛋白所致气道高反应性患者的咳嗽反射和气道反应性
J Mokry,G Nosalova
J Mokry
Stimulation of mechanoceptors is considered to be the major mechanism of cough. Our aim in this study was to evaluate the relationship between in vivo and in vitro airway reactivity (AR) in chemically- and antigen-induced airway hyperrespon...
Effects of meconium on airway reactivity to histamine and acetylcholine in vitro [0.03%]
胎粪对组胺和乙酰胆碱的气道反应性的影响
J Mokry,D Mokra,G Nosalova
J Mokry
To better understand the mechanisms contributing to altered airway reactivity in the meconium aspiration syndrome, in this study we investigated whether there could be a meconium dose-dependent response of tracheal smooth muscle and lung ti...
Aminophylline treatment in meconium-induced acute lung injury in a rabbit model [0.03%]
氨茶碱治疗兔胎粪吸入性急性肺损伤的效果观察
D Mokra,J Mokry,Z Tatarkova et al.
D Mokra et al.
Administration of methylxanthines may diminish meconium-induced acute lung injury. Meconium-instilled rabbits intravenously received aminophylline (2.0 mg/kg) at two doses 0.5 h and 2.5 h after meconium instillation or were left without tre...
Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits [0.03%]
经气管给药的皮质类固醇可改善兔胎粪吸入后的肺功能
D Mokra,J Mokry,A Drgova et al.
D Mokra et al.
Local administration of corticosteroids may diminish acute lung injury associated with meconium aspiration. Budesonide was given intratracheally in 2 doses of 0.25 mg/kg each by means of inpulsion effect of high-frequency jet ventilation 0....
Single-dose versus two-dose dexamethasone effects on lung inflammation and airway reactivity in meconium-instilled rabbits [0.03%]
单次与两次剂量地塞米松对兔胎粪吸入后肺部炎症和气道反应性的影响
D Mokra,J Mokry,A Drgova et al.
D Mokra et al.
Two doses of the corticosteroid dexamethasone may alleviate meconium-induced acute lung injury more effectively than a single dose. Meconium-instilled rabbits intravenously received dexamethasone (0.5 mg/kg) at one dose 0.5 hours after meco...