Repeated co-treatment with imipramine and amantadine induces hippocampal brain-derived neurotrophic factor gene expression in rats [0.03%]
反复使用阿米替林和金刚胺诱导大鼠海马脑源性神经营养因子基因的表达
Z Rogóz,G Skuza,B Legutko
Z Rogóz
The problem of drug-resistant depression indicates a strong need for alternative antidepressant therapies. In our earlier papers we described synergistic, antidepressant-like effects of a combination of imipramine (IMI) and amantadine (AMA)...
Deficiency of cyclooxygenases transcripts in cultured primary bronchial epithelial cells of aspirin-sensitive asthmatics [0.03%]
阿司匹林敏感性哮喘患者支气管上皮细胞环氧化酶表达降低
M Pierzchalska,J Soja,M Woś et al.
M Pierzchalska et al.
Background: Airway function is actively regulated by epithelium through generating PGE(2), the production of which depends on cyclooxygeneses (COX-1 and COX-2). Analysis of bronchial biopsies and bronchial epithelial cell...
Homocysteine induces endothelial dysfunction via inhibition of arginine transport [0.03%]
同型半胱氨酸通过抑制精氨酸运输诱导血管内皮功能障碍
L Jin,R B Caldwell,T Li-Masters et al.
L Jin et al.
Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. High levels of plasma homocysteine (HCY) increase oxidative stress and reduce endothelial-dependent relaxation. We determined whether hyperhomocysteinemia-induc...
Effects of somatostatin-14 and the receptor-specific somatostatin analogs on chromogranin A and alpha-subunit (alpha-SU) release from "clinically nonfunctioning" pituitary adenoma cells incubated in vitro [0.03%]
生长抑素-14及受体特异生长抑素类似物对培养的临床非功能性垂体腺瘤细胞中肾上腺源性蛋白A和α亚基释放的影响研究
M Pawlikowski,H Lawnicka,H Pisarek et al.
M Pawlikowski et al.
The aim of the study was to examine the effect of somatostatin (SST) and its analogs on the release of chromogranin A (CgA) and alpha-subunit (alpha-SU) from clinically non-functioning pituitary adenomas incubated in vitro. Seven pituitary ...
The effects of indomethacin on angiogenic factors mRNA expression in renal cortex of healthy rats [0.03%]
吲哚美辛对健康大鼠肾脏皮质促血管生成因子mRNA表达的影响
K Mucha,B Foroncewicz,K Koziak et al.
K Mucha et al.
Indomethacin is a nonsteroidal anti-inflammatory drug used frequently to control chronic or temporary pain. In the kidney, indomethacin decreases medullary and cortical perfusion, resulting in hypoxia. Kidney hypoxia has many effects, inclu...
Renal tissue NO and intrarenal haemodynamics during experimental variations of NO content in anaesthetised rats [0.03%]
麻醉大鼠实验性改变一氧化氮含量时的肾组织一氧化氮和肾内血流动力学变化
M Grzelec-Mojzesowicz,J Sadowski
M Grzelec-Mojzesowicz
Direct renal nitric oxide (NO) measurements were infrequent and no simultaneous measurements of renal cortical and medullary NO and local perfusion. Large-surface NO electrodes were placed in renal cortex and medulla of anaesthetised rats; ...
J Jaworek,S J Konturek,M Macko et al.
J Jaworek et al.
Bacterial endotoxin (lipopolysaccharide, LPS), at high concentration is responsible for sepsis, and neonatal mortality, however low concentration of LPS protected the pancreas against acute damage. The aim of this study was to investigate t...
Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells [0.03%]
瘦素干扰胃粘膜细胞中幽门螺旋杆菌脂多糖诱导的胞浆磷脂酶A₂活化作用
B L Slomiany,A Slomiany
B L Slomiany
Activation of cytosolic phospholipase A(2) (cPLA(2)) by bacterial LPS for the rapid release of arachidonic acid from membrane phospholipids is considered a key step in the generation of platelet-activating factor (PAF), recognized as the mo...
The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats [0.03%]
肾上腺切除大鼠红细胞和胃组织抗氧化状态的相互作用及泼尼松龙和肾上腺素的作用研究
A Yildirim,Y N Sahin,H Suleyman et al.
A Yildirim et al.
It has been believed that overproduction of free radicals and/or deficiency of antioxidant systems, and stress hormones may play a role in etiopathogenesis of many diseases, including gastric ulcer. This study evaluated whether there was an...
Postural changes associated with public speech tests lead to mild and selective activation of stress hormone release [0.03%]
与公共演讲测试相关的姿态变化会导致应激激素释放的轻度和选择性激活
M Mlynarik,A Makatsori,I Dicko et al.
M Mlynarik et al.
We tested whether simulation of postural changes, which occur during public speech test procedures, activates cardiovascular system and stress hormone release that could interfere with the effect of psychosocial stress load. Young healthy m...