The effect of concomitant stimulation with cholecystokinin and epidermal growth factor on extracellular signal-regulated kinase (ERK) activity in pancreatic acinar cells [0.03%]
胆囊收缩素与表皮生长因子联合刺激对胰腺腺泡细胞外信号调节激酶活性的影响
J Daniluk,A Dabrowski
J Daniluk
The transmission of extracellular proliferation and differentiation signals into their intracellular targets is mediated by a signaling cascade culminating in mitogen-activated protein kinase (MAPK) also known as ERK. In pancreatic acinar c...
Modulation of CCK-8-evoked intracellular Ca2+ waves by hydrogen peroxide in mouse pancreatic acinar cells [0.03%]
氢 Peroxide 对胆囊收缩素八肽所致小鼠胰腺 acini 内钙波的调制作用研究
M P Granados,G M Salido,J A Pariente et al.
M P Granados et al.
In the present study we have employed single cell imaging analysis to monitor the propagation of cholecystokinin-evoked Ca(2+) waves in mouse pancreatic acinar cells. Stimulation of cells with 1 nM CCK-8 led to an initial Ca(2+) release at ...
Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach [0.03%]
前列腺素E EP3亚型受体和前列环素IP受体在胃损伤区酸分泌减少中的作用机制研究
H Nishio,S Terashima,M Nakashima et al.
H Nishio et al.
We investigated the roles of cyclooxygenase (COX) isozymes and prostaglandin E (PGE) receptor EP1 and EP3 subtypes or prostacyclin IP receptors in the decrease in acid secretion in the damaged mouse stomach. Male C57/BL6 mice, both wild typ...
Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT) [0.03%]
胃肠道中的褪黑素的定位及其生物学活性
S J Konturek,P C Konturek,I Brzozowska et al.
S J Konturek et al.
Melatonin (MT), an indole formed enzymatically from L-trytophan (Trp), was first discovered in the bovine pineal gland in 1958 by Lerner et al. Melatonin is the most versatile and ubiquitous hormonal molecule produced not only in the pineal...
Endotoxemia in the infant rats modulates HSP60 protein level in the pancreatic acinar cells [0.03%]
内毒素血症通过调节胰腺泡中的HSP60蛋白水平影响幼年大鼠胰腺功能
J Bonior,J Jaworek,M Kot et al.
J Bonior et al.
Lipopolysaccharide (endotoxin, LPS) is responsible for septic shock and multiorgan failure, but pretreatment of the rats with low doses of LPS reduced pancreatic damage produced by caerulein-induced pancreatitis (CIP). In spite of this obse...
Melatonin stimulates HSP27 phosphorylation in human pancreatic carcinoma cells (PANC-1) [0.03%]
褪黑激素刺激人胰腺癌细胞(HPPAN-C1)中HSP27的磷酸化
A Leja-Szpak,J Jaworek,J Szklarczyk et al.
A Leja-Szpak et al.
Heat shock protein 27 (HSP27) is a cytoprotective chaperone, activated by stressful stimuli. HSP27 modulates aggregation and degradation of many proteins. Recent evidence suggests that HSP27 could be involved in the progression of tumor gro...
Sodium butyrate-dependent sensitization of human colon adenocarcinoma COLO 205 cells to TNF-alpha-induced apoptosis [0.03%]
丁酸钠诱导的人类结肠腺癌COLO 205细胞对TNF-α所致凋亡的敏感性增强
B Pajak,A Orzechowski
B Pajak
COLO 205 colon adenocarcinoma cells are highly resistant to extrinsic apoptosis induced by immunomodulatory cytokines. One of the antiapoptotic mechanisms is the expression of cFLIP protein, which inhibits TNF-alpha-induced cell death. The ...
Involvement of sensory afferent fibers and lipid peroxidation in the pathogenesis of stress-induced gastric mucosa damage [0.03%]
感觉纤维和脂质过氧化在应激性胃黏膜损伤发病中的作用
S Kwiecień,M W Pawlik,Z Sliwowski et al.
S Kwiecień et al.
Ablation of sensory nerves impairs healing of gastric ulcers, but the role of free radicals in the healing process has been little studied. The aim of our present investigations was to determine the participation of reactive oxygen species ...
Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins [0.03%]
辛伐他汀抑制巴雷特食管腺癌细胞增殖的作用及机制研究
P C Konturek,G Burnat,E G Hahn
P C Konturek
Recent studies demonstrated that inhibitors of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMG-CoAR), called "statins", independently of their well known plasma cholesterol lowering effect, exert favourable influence on a diverse range...
Dysfunction of the autonomic nervous system activity is responsible for gastric myoelectric disturbances in the irritable bowel syndrome patients [0.03%]
自主神经系统的功能紊乱导致易激惹肠综合症患者的胃电活动异常
M Mazur,A Furgała,K Jabłoński et al.
M Mazur et al.
The pathogenesis of the irritable bowel syndrome (IBS) is still unsolved. Lately most attention has been focused on visceral hypersensitivity related to dysfunction of the autonomic nervous system (ANS). The aim of this study was to evaluat...