BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice [0.03%]
BAY x 1005可减轻载脂蛋白E/低密度脂蛋白受体双敲除小鼠的动脉粥样硬化病变
J Jawień,M Gajda,R Olszanecki et al.
J Jawień et al.
Recently, we have shown that MK-886 - an inhibitor of five lipoxygenase activating protein (FLAP) inhibits atherosclerosis in apolipoprotein E / LDL receptor - double knockout mice. We, therefore, wanted to find out if other FLAP inhibitor ...
Leptin gene and protein expression in the trophoblast and uterine tissues during early pregnancy and the oestrous cycle of pigs [0.03%]
猪妊娠早期和发情周期子宫及滋养层组织中瘦素基因与蛋白的表达
N Smolinska,G Siawrys,T Kaminski et al.
N Smolinska et al.
Leptin is a 16-kDa protein hormone encoded by the obese (ob) gene and acts on receptors in the hypothalamus to regulate food intake and energy balance. The identification of leptin and its receptor mRNAs and proteins in human and mouse endo...
Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors attenuates fever due to LPS in rats [0.03%]
神经元型和诱导型一氧化氮合酶抑制剂对内毒素发热的拮抗作用
D Soszynski,M Chelminiak
D Soszynski
Nitric oxide (NO) has been shown to be an important mediator of febrile response to lipopolisaccharide (LPS). To clarify the role of different isoforms of NO synthase (NOS) in febrile response to immune challenge, effects of selective iNOS ...
Protective effects of early treatment with lipoic acid in LPS-induced lung injury in rats [0.03%]
早期用硫辛酸处理对脂多糖致大鼠肺损伤的保护作用
A Goraca,G Józefowicz-Okonkwo
A Goraca
A lipopolysaccharide (LPS) stimulates the synthesis and releases several metabolites from phagocytes which can lead to an endotoxic shock characterized by multiple organ injury with the earliest to occur in the lungs. Among LPS-induced meta...
Measurement of angiotensin metabolites in organ bath and cell culture experiments by liquid chromatography - electrospray ionization - mass spectrometry (LC-ESI-MS) [0.03%]
采用液相色谱-电喷雾串联质谱法测定组织浴和细胞培养实验中的血管紧张素代谢产物
B Bujak-Gizycka,J Madej,P P Wołkow et al.
B Bujak-Gizycka et al.
The metabolism of renin-angiotensin system (RAS) is more complicated than previously expected and understanding the biological phenomena regulated by variety of angiotensin metabolites requires their precise and possibly comprehensive quant...
A Mogielnicki,K Kramkowski,L Pietrzak et al.
A Mogielnicki et al.
There are few findings indicating that nicotinamide may potentially influence intravascular thrombosis. Interestingly, N-methylnicotinamide, one of the metabolites of nicotinamide - could be more potent than its parent compound. In the pres...
Isoprenoid depletion by statins antagonizes cytokine-induced down-regulation of endothelial nitric oxide expression and increases NO synthase activity in human umbilical vein endothelial cells [0.03%]
他汀类药物诱导的异戊二烯缺乏可拮抗细胞因子介导的内皮一氧化氮合酶表达下调并增加人脐静脉内皮细胞中一氧化氮合成酶活性
F Jantzen,S Könemann,B Wolff et al.
F Jantzen et al.
Endothelial dysfunction and atherosclerosis are associated with an inflammation-induced decrease in endothelial nitric oxide synthase (eNOS) expression. Based on the differences between hydrophobic and hydrophilic statins in their reduction...
Effect of galanin on substance P- and vasoactive intestinal polypeptide-induced nociceptive trigemino-hypoglossal reflex in rats [0.03%]
加压素对大鼠缓激肽和血管活性肠肽诱发的伤害性三叉咽反射的影响
M Zubrzycka,A Janecka
M Zubrzycka
Substance P (SP), vasoactive intestinal polypeptide (VIP) and galanin (GAL), present in primary sensory neurons, are involved in transmission of nociceptive signaling from the peripheral to central nervous system. In this study we investiga...
An immunohistochemical study of endocrine cells in the stomach of hypertensive rats [0.03%]
高血压大鼠胃内分泌细胞的免疫组化研究
I Kasacka,M Majewski
I Kasacka
Essential hypertension is a complex disease with both genetic and environmental determinants. The effect of spontaneous hypertension on the distribution and occurrence of somatostatin-, gastrin- and serotonin-immunoreactive cells in the fun...
Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats [0.03%]
蒙特鲁卡斯特对预防硫酸葡聚糖钠致轻度结肠炎的保护作用
R Holma,P Salmenperä,I Virtanen et al.
R Holma et al.
Cysteinyl leukotrienes play a part in inflammatory processes such as inflammatory bowel diseases. The present study aimed to evaluate the effects of the cys-LT-1 receptor antagonist montelukast on a mild colitis model in rats. Colitis was i...