Influence of melatonin and its precursor L-tryptophan on Th1 dependent contact hypersensitivity [0.03%]
褪黑素及其前体左旋色氨酸对Th1依赖性接触超敏反应的影响
M Majewska,K Zajac,M Zemelka et al.
M Majewska et al.
There is strong evidence that melatonin possesses immunomodulatory activity. It has been shown that it enhances the immune response, acting as a pro-inflammatory agent. It is suggested that melatonin promotes Th1-mediated immune responses b...
M Szczepanik
M Szczepanik
Melatonin was initially extracted from the pineal gland and was thought to be produced exclusively by this organ. Subsequently it was shown that melatonin is also produced in other tissues including the gastrointestinal tract, retina and ce...
M Karasek
M Karasek
Increasing number of people in advanced age is one of the most distinctive demographic events of the 21(st) century which raise many social and medical issues. Therefore, there is a search for any therapeutic agent improving the quality of ...
P J Thor,G Krolczyk,K Gil et al.
P J Thor et al.
The gastrointestinal tract represents the most important extra pineal source of melatonin. Presence of melatonin (M) suggests that this hormone is somehow involved in digestive pathophysiology. Release of GI melatonin from serotonin-rich en...
Involvement of vagal nerves in the pancreatostimulatory effects of luminal melatonin, or its precursor L-tryptophan. Study in the rats [0.03%]
胃泌素释放肽对大鼠胰腺分泌作用的迷走神经参与及壁内途径的研究
K Nawrot-Porabka,J Jaworek,A Leja-Szpak et al.
K Nawrot-Porabka et al.
Melatonin, known as a product of pineal gland is also produced in the digestive system. Melatonin receptors have been detected on pancreatic beta cells and this indoloamine influences the endocrine pancreatic function but the role of melato...
Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector [0.03%]
褪黑素对胰酶分泌的调节及胰腺保护作用
J Jaworek,K Nawrot-Porabka,A Leja-Szpak et al.
J Jaworek et al.
Melatonin, the main product of the pineal gland, is also released from the gastrointestinal endocrine-neurocrine (EE) cells. The concentrations of melatonin produced in the gut exceeds that originating from central nervous system. In spite ...
Role of circadian rhythm and endogenous melatonin in pathogenesis of acute gastric bleeding erosions induced by stress [0.03%]
应激诱发急性胃黏膜病变的昼夜节律及内源性褪黑素作用的研究进展
T Brzozowski,K Zwirska-Korczala,P C Konturek et al.
T Brzozowski et al.
Stress that appears as a consequence of burns, surgical trauma and life threatening conditions is a serious clinical entity, can result in acute gastric mucosal lesions. Such stress lesions can develop in response to the imbalance between t...
S J Konturek,P C Konturek,T Brzozowski et al.
S J Konturek et al.
Melatonin, an indole formed enzymatically from L-tryptophan, is the most versatile and ubiquitous hormone molecule produced not only in all animals but also in some plants. This review focuses on the role of melatonin in upper portion of ga...
Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage [0.03%]
褪黑素清除神经源性自由基并减少相关的神经形态学和神经行为损伤
R J Reiter,D-X Tan,L C Manchester et al.
R J Reiter et al.
Melatonin and its metabolites are potent antioxidants by virtue of their ability to scavenge both oxygen-based and nitrogen-based radicals and intermediates but also as a consequence of their ability to stimulate the activity of antioxidati...