Peripheral-type mitochondrial binding sites for benzodiazepines in GH3 pituitary cells [0.03%]
GH3垂体细胞周边型苯二氮卓受体及与线粒体的结合部位
M C Gershengorn,V S Purrello,E Geras-Raaka
M C Gershengorn
Benzodiazepines (BZs) interact with two classes of high affinity binding sites, equilibrium dissociation constants in the nanomolar range, a neuronal or central-type and a non-neuronal or peripheral-type. The peripheral-type binding site ha...
S K West,J M Oosthuizen
S K West
The hormone, melatonin, is a product of the pineal gland. This methoxy-indole, also known as N-acetyl-5-methoxy-tryptamine, is structurally related to indomethacin, a derivative of methylated indole. The fact that indomethacin has been used...
M J Flanigan,Q Accone,H P Laburn
M J Flanigan
We investigated the effect of a tricyclic antidepressant (TCA) agent on fever in rabbits. In the first series of experiments, the TCA agent amitriptyline hydrochloride (AMI) was administered intraperitoneally (i.p.) at a dose of 1 mg/kg or ...
A Czyrak,Z Rogóz,G Skuza et al.
A Czyrak et al.
S-Adenosyl-L-methionine (SAM), main methyl donor, was tested in mice and rats in several models which are predictive of possible antidepressant activity. In the forced swimming test in rats the effect of SAM was compared with that of the tr...
Effect of benzodiazepine ligands on Ca2+ channel currents in Xenopus oocytes injected with rat heart RNA [0.03%]
苯二氮平配体对注入大鼠心肌细胞mRNA的非洲爪蟾卵母细胞Ca2+通道电流的影响
E Gershon
E Gershon
Voltage-dependent Ca2+ channel (VDCC) currents have been measured in Xenopus oocytes injected with heart RNA purified from 7 day old rats, using voltage clamp technique. The currents were evoked by depolarizing voltage steps, using Ba2+ as ...
A Mayevsky,K Frank,M Muck et al.
A Mayevsky et al.
We have developed the multiprobe assembly (MPA) by which metabolic, ionic and electrical activities can be monitored from the surface of the brain. In the present study we included optical fibers for the monitoring of intracapillary hemoglo...
D Lichtstein,S Samuelov,I Gati et al.
D Lichtstein et al.
The Na+, K+ activated adenosine triphosphatase is present in the membrane of eukaryotic cells and represents a major pathway for Na+ and K+ transport across the plasma membrane. Cardiac glycosides such as ouabain or digoxin suppress this en...
Pinealectomy but not melatonin supplementation affects the diurnal variations in 125I-melatonin binding sites in the rat brain [0.03%]
松果体切除术而非补充褪黑激素影响大鼠脑中125I-褪黑激素结合位点的昼夜变化规律
S Oaknin-Bendahan,Y Anis,I Nir et al.
S Oaknin-Bendahan et al.
The distribution of melatonin binding sites in synaptosomal preparations from five brain areas of sham-operated and pinealectomized young male rats (maintained in a 14 h light: 10 h darkness cycle; lights on at 5.00 h) was recorded at 10.00...
Aging does not alter the binding characteristics to voltage dependent calcium channels in the brain of CW1 mice [0.03%]
衰老不影响CW1小鼠脑内电压门控钙通道的结合特性
A Golik,T Kadar,L Raveh et al.
A Golik et al.
Structural age-related changes in cholinergic regions within the central nervous system of CW1 mice have been described previously. Since elevated calcium concentration has been suggested to play a role in the brain aging processes, the pos...