P J Roach,C Cheng,D Huang et al.
P J Roach et al.
The storage polysaccharide glycogen is widely distributed in nature, from bacteria to mammals. Study of its regulated accumulation has resulted in the discovery or elaboration of several important biochemical principles. Many aspects of the...
Phosphoinositol glycan derived mediators and insulin resistance. Prospects for diagnosis and therapy [0.03%]
磷脂酰肌醇糖基化介导物与胰岛素抵抗：诊断和治疗的前景
J Larner,G Allan,C Kessler et al.
J Larner et al.
While much work remains, the evidence has become strong that IPG generation following insulin action is a significant signaling mechanism. A considerable body of data has established IPG release by insulin and other growth factors from cell...
Inhibition of the transmembrane protein tyrosine phosphatase lar by 3S-peptide-I enhances insulin receptor phosphorylation in intact cells [0.03%]
3S-肽-I抑制跨膜蛋白酪氨酸磷酸酶lar可增强完整细胞中的胰岛素受体磷酸化
H K Kole,S Kole,B P Mallory et al.
H K Kole et al.
3S-peptide-I, a tris-sulfotyrosyl dodecapeptide that corresponds to the major autophosphorylation domain within the insulin receptor beta-subunit, selectively enhances insulin signal transduction by specifically inhibiting dephosphorylation...
The insulin receptor--a critical link in glucose homeostasis and insulin action [0.03%]
胰岛素受体——葡萄糖稳态和胰岛素作用的关键环节
M E Patti,C R Kahn
M E Patti
We have achieved significant progress in understanding the central role of the insulin receptor in an increasingly complicated web of intracellular signal transduction leading to the ultimate biological actions of insulin on glucose, lipid,...
G Stendig-Lindberg,D Moran,Y Shapiro
G Stendig-Lindberg
Nine apparently healthy male subjects, mean age 22.8 yr, SD 4.1, free from disease, medication or addiction who gave informed consent, underwent acclimation process in a heat chamber; exposed during 2 h daily for 10 consecutive days to a te...
T Morimoto,T Itoh
T Morimoto
Thermoregulatory responses induce dehydration, and dehydration itself raises body temperature, causing an increase in the threshold temperature for cutaneous vasodilatation and sweating, the sensitivity of cutaneous vasodilatation in respon...
Energy expenditure and efficiency of energy use in rodents: desert and non-desert species [0.03%]
啮齿动物的能量消耗及能量利用效率：荒漠和非荒漠物种
A A Degen
A A Degen
Feeding and the search for food are the predominant activities of most rodents. Since desert rodents inhabit regions of generally low food availability, it has been theorized that their energetic requirements would be lower and/or their eff...
Y Arieli,J Marder
Y Arieli
This review presents an overview of the puzzle called "cutaneous water evaporation (CWE) cooling mechanism" in birds. Heat acclimation of the rock pigeon induces cellular modifications that affect the myocardium, cutaneous vasculature, and ...
M Cabanac
M Cabanac
During heat stress, the function of selective brain cooling puts trunk core temperature in an open-loop situation. As a result, trunk core temperature deviates more than expected, while brain temperature remains lower than trunk temperature...
L Zhu,J Gao,Y Wang et al.
L Zhu et al.
Calcium channel blockers are used as neuroprotective agents, as glutamate antagonists. However, it has been found that calcium channel blockers may compromise neuronal survival after long-term exposure. To explore the mechanisms of the toxi...