Changes in effective and lethal doses of intravenous anesthetics and lidocaine when used in combination in mice [0.03%]
联合使用静脉麻醉药和利多卡因时的有效剂量和致死剂量的变化
M Barak,I Ben-Shlomo,Y Katz
M Barak
We studied the interactions between a local anesthetic agent, lidocaine, and two general anesthetic drugs, propofol and ketamine, in mice. We used two end points: hypnosis, reflected by loss of the righting reflex, and death. The ED50 for h...
Effect of cefaperazone/sulbactam and ampicillin/sulbactam on the in vitro activity of human erythrocyte glucose-6-phosphate dehydrogenase [0.03%]
头孢泊肟/舒巴坦和氨苄西林/舒巴坦对人红细胞葡萄糖-6-磷酸脱氢酶体外活性的影响
M Ciftçi,M E Büyükokuroğlu,O I Küfrevioğlu
M Ciftçi
We investigated the effects of the antibiotic drugs cefaperazone/sulbactam and ampicillin/sulbactam on the in vitro activity of the enzyme glucose-6-phosphate dehydrogenase (G6PD). The enzyme was purified from human erythocytes using 2',5' ...
Renovascular actions of adenosine in the isolated perfused rat kidney: possible underlying mechanisms [0.03%]
腺苷在分离的灌注大鼠肾脏中的血管作用及其潜在机制
C Küçükhüseyin,N Akbaş,C Silan et al.
C Küçükhüseyin et al.
We studied the renovascular action of adenosine on isolated perfused rat 10 min after drug injections. Adenosine was applied intraarterially as a single bolus injection in logarithmically increasing doses (0.3-30 microg). Adenosine treatmen...
Effect of ondansetron on the contractile responses to positive inotropic agents in electrically driven left atria of rats [0.03%]
昂丹司琼对电驱动大鼠左心房收缩反应的影响
C Küçükhüseyin,N Akbaş,D O Yillar
C Küçükhüseyin
We studied the interaction of ondansetron with positive inotropic agents, including serotonin (5-hydroxytryptophane, 5-HT), noradrenaline, 4-aminopyridine (4-AP), calcium chloride, or with reserpine in isolated electrically driven rat atria...
Effect of nitric oxide synthase inhibition on the gastric mucosal barrier in rats [0.03%]
一氧化氮合酶抑制对大鼠胃粘膜屏障的影响
V N Izgut-Uysal,N Derin,I Kaputlu
V N Izgut-Uysal
The aim of this study was to investigate the effect of N-G-nitro-L-arginine-methyl ester (L-NAME), a nitric oxide synthase inhibitor, on the gastric mucosal barrier in rats. A group of Swiss albino rats received L-NAME (60 mg/kg/d) in their...
Effect of hyperoxia and metformin on vascular responses to vasoactive compounds in rats [0.03%]
富氧及美格菲对血管收缩舒张反应的影响
S Ozyazgan,E Ince,V Senses et al.
S Ozyazgan et al.
Exposure of cells to oxygen concentrations higher than normal (hyperoxia) damages the molecular components of cells, resulting in cellular dysfunction and death. Metformin, a biguanide molecule used for treating non-insulin-dependent diabet...
Effect of 5-aminoimidazole-4-carboxamide riboside (AICA-r) on isolated thoracic aorta responses in streptozotocin-diabetic rats [0.03%]
5-氨基咪唑-4-甲酰胺核糖苷(AICAR)对链脲佐菌素糖尿病大鼠胸主动脉环反应的影响
V Senses,S Ozyazgan,E Ince et al.
V Senses et al.
Diabetes mellitus alters the vascular responsiveness to several vasoconstrictors and vasodilators. 5-amino-4-imidazole-carboxamide riboside (AICA-r), a nucleoside corresponding to AICA-ribotide and an intermediate of the de novo pathway of ...
Possible mechanisms for the anti-implantation action of dicofol in albino rats [0.03%]
有关Dicofol在白色大鼠身上产生防着床作用的可能机制
U C Jadaramkunti,B B Kaliwal
U C Jadaramkunti
Dicofol, a chlorinated pesticide showing estrogenic activity, was administered orally to virgin pregnant rats at doses of 300, 400, 500, 600, or 700 mg/kg/day for 7 consecutive days to examine its effect on blastocyst implantation. One grou...
Effects of acamprosate and scopolamine on the working memory of rats in a three-panel runway task [0.03%]
醋氨酚和东莨菪碱对三板跑道任务中大鼠工作记忆的影响
I Okulicz-Kozaryn,P Midolajczak,K Szczawinska et al.
I Okulicz-Kozaryn et al.
The aim of this study was to evaluate the effect of treatment with single (1x) and multiple (10x) doses of the anti-craving compound acamprosate (AC, calcium acetyl homotaurinate) on working memory in rats, using in a three-panel runway tes...
The influence of ascorbic acid on nickel-induced hepatic lipid peroxidation in rats [0.03%]
抗坏血酸对镍致大鼠肝脂质过氧化作用的影响
K K Das,S N Das,S DasGupta
K K Das
We studied the effect of oral ascorbic acid treatment on nickel sulfate-induced lipid peroxidation in the liver of Wistar strain male albino rats. Lipid peroxide and glutathione levels and the activities of the antioxidant enzymes superoxid...