Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study [0.03%]
大鼠帕瑞昔布诱导肝毒性的磷二酯酶同工酶抑制的调节作用初步研究
Martins Ekor,Adesina O Odewabi,Oluwafemi E Kale et al.
Martins Ekor et al.
Background: Altered regulation of nitric oxide-cyclic guanosine monophosphate (NO-cGMP) is present in liver cirrhosis. Several experimental studies have shown that selective modulation of NO metabolism in the liver reduce...
Dexamethasone decreases the spermidine and spermine concentrations and polyamine oxidase activity in rat thymus [0.03%]
地塞米松降低大鼠胸腺精胺和亚精胺浓度以及多胺氧化酶活性
Gordana Bjelaković,Dusica Pavlovic,Gordana Kocic et al.
Gordana Bjelaković et al.
Background: Glucocorticoids (GCs) exert a wide range of anti-inflammatory, immunosuppressive, and antineoplastic activities. The aim of our investigation was to elucidate the effect of dexamethasone, a synthetic GC, on po...
Non-hydrolyzed in digestive tract and blood natural L-carnosine peptide ("bioactivated Jewish penicillin") as a panacea of tomorrow for various flu ailments: signaling activity attenuating nitric oxide (NO) production, cytostasis, and NO-dependent inhibition of influenza virus replication in macrophages in the human body infected with [0.03%]
非水解消化道和血液天然L-卡尼丁肽（“生物活化犹太青霉素”）作为流感等各种流感疾病的灵丹妙药：信号活性降低一氧化氮(NO)产生，细胞静止和NO依赖性抑制人体内感染的流感病毒复制在巨噬细胞中
Mark A Babizhayev,Anatoliy I Deyev,Yegor E Yegorov
Mark A Babizhayev
Influenza (flu) is caused by a highly contagious virus that is spread by coughs and sneezes. Flu symptoms include high fever, chills and sweating, sore throat, weakness, headache, muscle and joint pains, and cough. Older people and those wi...
Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut [0.03%]
实验内毒素血症中抑制内源大麻素分解可减少白细胞黏附并改善肠道毛细血管灌注
Mandana Kianian,Nadia A Al-Banna,Melanie E M Kelly et al.
Mandana Kianian et al.
Background: Changes in leukocyte-endothelial and microvascular perfusion are hallmark events in inflammation. Thus, protection of the intestinal microcirculation represents a pivotal therapeutic target in systemic inflamm...
Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts [0.03%]
神经生长因子减少大鼠心脏缺血/再灌注损伤
Jennifer L Strande,Kasi V Routhu,Shimon Lecht et al.
Jennifer L Strande et al.
Background: Nerve growth factor (NGF) is a neurotrophin that supports the survival and differentiation of sympathetic neurons, and its increased expression after myocardial infarct was correlated with cardiac sympathetic ...
Beneficial effect of Trichopus zeylanicus extract on mercuric chloride-induced hepatotoxicity in rats [0.03%]
化州柚提取物对汞氯诱导的实验性大鼠肝损伤的影响研究
Nallasamy Palanisamy,Selvam Mohan Dass
Nallasamy Palanisamy
Background: The present study aimed to determine the effect of Trichopus zeylanicus leaf extract (TZ Et) on mercuric chloride (HgCl2)-induced liver toxicity in rats. ...
Protective role of ferulic acid on carbon tetrachloride-induced hyperlipidemia and histological alterations in experimental rats [0.03%]
对羟基苯甲酸通过减轻CCl4所致血脂异常和肝组织损伤保护肝脏作用的研究
Srinivasan Marimuthu,Ram Sudheer Adluri,Rukkumani Rajagopalan et al.
Srinivasan Marimuthu et al.
Background: The present study aimed to evaluate the antihyperlipidemic effect of ferulic acid (FA) on carbon tetrachloride (CCl4)-treated rats. Methods: ...
Diethylnitrosamine-induced redox imbalance in rat microsomes: protective role of polyphenolic-rich extract from Sorghum bicolor grains [0.03%]
二乙基亚硝胺诱导的大鼠微粒体氧化应激失衡及其抗氧化物质的保护作用：用高梁谷物多酚富集提取物为例
Taofeek Olakunle Ajiboye,Yesirat Omonike Komolafe,Hussein Oyelola Bukoye Oloyede et al.
Taofeek Olakunle Ajiboye et al.
Background: This study investigates the protective role of polyphenolic-rich extract from Sorghum bicolor against diethylnitrosamine (DEN)-induced redox imbalance in rat microsomes. ...
Preclinical evaluation of hypoglycemic activity of Ipomoea digitata tuber in streptozotocin-induced diabetic rats [0.03%]
预印本评价牵牛属植物_DIGITATA_根系在糖尿病大鼠中的降血糖活性
Awanish Kumar Pandey,Prem Prakash Gupta,Vijay Kumar Lal
Awanish Kumar Pandey
Background: The use of medicinal plants has turned out to be an alternative method for the treatment of diseases, such as diabetes mellitus. The recommendation of the World Health Organization Committee on Diabetes encour...
Hepatoprotective effects of hydroalcoholic extract of Allium hirtifolium (Persian shallot) in diabetic rats [0.03%]
Allium hirtifolium（波斯沙葱）的羟乙醇提取物对糖尿病大鼠的肝保护作用
Hosseini Javad,Hosseini-Zijoud Seyed-Mostafa,Oubari Farhad et al.
Hosseini Javad et al.
Background: The prevalence of diabetes mellitus (DM) is dramatically increasing worldwide. Prospective studies have reported that high levels of hepatic enzymes, including aspartate aminotransferase (AST), alanine aminotr...