Naoki Kinoshita,Mitsuhiro Yamamoto,Tomoyuki Ikeuchi et al.
Naoki Kinoshita et al.
Background: Performance status is a useful prognostic index in palliative care. The objectives of this study were to investigate the prognosis of near-end-of-life patients with advanced lung cancer admitted due to deterio...
Next-Generation Artificial Intelligence for ADME Prediction in Drug Discovery: From Small Molecules to Biologics [0.03%]
下一代人工智能在药物发现中的ADMET预测应用：从小分子到生物大分子
Soyoka Tanihata,Hiroaki Iwata
Soyoka Tanihata
Pharmacokinetic (PK) behavior, which emerges from the underlying processes of absorption, distribution, metabolism, and excretion (ADME), is central to drug discovery and development, dose optimization, and safety assessment. Despite decade...
Association Between Underweight Status and Social Jet Lag Among Japanese University Students: A Cross-Sectional Study with Sex-Specific Analysis [0.03%]
日本大学生中体重偏低与社会性时差关联的性别特异性分析横断面研究
Shinobu Sugihara,Ryo Miyazaki,Masahiko Kato
Shinobu Sugihara
Background: The prevalence of underweight among young adults in Japan is approximately 20% in both males and females. Despite its potential health risks, underweight in males has received limited attention. Social jet lag...
Massive Small Bowel Resection Induces IFALD-Like Liver Injury in Mice [0.03%]
小肠切除诱导的小鼠肝胆疾病样肝损伤模型的建立及中药复方治疗研究
Kohga Masuda,Yugo Kato,Yosuke Horikoshi et al.
Kohga Masuda et al.
Background: Severe short bowel syndrome (SBS) frequently leads to intestinal failure-associated liver disease (IFALD); nonetheless, the mechanisms underlying early hepatic changes remain unclear. Existing SBS rodent model...
A Questionnaire Survey on Human Papillomavirus Vaccination Among Hospital-Based Healthcare Professionals [0.03%]
针对基于医院的医疗保健专业人员的人乳头瘤病毒疫苗接种问卷调查
Ayami Kimura,Tetsuro Oishi,Rina Fujioka et al.
Ayami Kimura et al.
Background: Although active human papillomavirus (HPV) vaccination recommendations resumed in Japan in 2022, vaccination rates remain low. Understanding hospital staff attitudes toward HPV vaccination may provide insights...
Association of Labor Epidural Analgesia with Neonatal Umbilical Arterial Blood pH and Apgar Score: The Japan Environment and Children's Study (JECS) [0.03%]
关于分娩时期硬膜外镇痛与新生儿脐带动脉血pH值及Apgar评分关联性的研究：日本环境儿童研究项目(JECS)
Misako Suto,Youichi Kurozawa,Shinji Otani et al.
Misako Suto et al.
Background: Labor epidural analgesia is recognized worldwide as the gold standard for maternal pain relief during delivery and has been increasingly used in Japan. However, studies on labor analgesia in Japan are scarce, ...
Questionnaire Survey on the Challenges and Questions Faced by Primary Care Physicians When Providing Care to Patients with Blood Disorders [0.03%]
初级保健医生诊治血液病患者所面临的挑战和问题的问卷调查
Shintaro Imaoka,Daisuke Son,Toshihiro Hamada et al.
Shintaro Imaoka et al.
Background: Collaboration between hematologists and primary care physicians (PCPs) is crucial for managing hematologic diseases, particularly malignancies. However, the specific challenges PCPs face in such coordination r...
Sosuke Kakee,Hiroaki Funata,Keisuke Okuno et al.
Sosuke Kakee et al.
Kimura disease is a chronic inflammatory disorder characterized by peripheral eosinophilia, elevated serum IgE levels, and a painless mass. Although it predominantly affects adult males, pediatric cases have also been reported. We report tw...
Investigating the Impact of Drinking Water on Urban Stunting in Indonesia [0.03%]
探究饮用水对印度尼西亚城市地区生长迟缓影响的研究
Arwinda Nugraheni,Muflihatul Muniroh,Dodik Pramono et al.
Arwinda Nugraheni et al.
Background: In Indonesia, stunting remains a health issue among children aged < 5 years, with a prevalence of 36.8% in 2021, the highest prevalence of malnutrition in the said age group, and the quality of drinking water ...
Association of Resilience with Psychological Distress, Burnout, and Depression Among Direct Support Professionals: A Cross-Sectional Study During the COVID-19 Pandemic [0.03%]
新冠肺炎疫情期间支持性专业人员的心理韧性与其心理困扰、职业枯竭及抑郁的关系：横断面研究
Daisaku Nishimoto,Shimpei Kodama,Yusaku Uemura et al.
Daisaku Nishimoto et al.
Background: COVID-19 pandemic-related changes have increased mental health problems of essential workers. However, little is known about its impact on direct support professionals (DSPs) working at facilities for people w...