[Application and development of in vitro metabolism study at early drug discovery stage] [0.03%]
[体外代谢研究在药物发现早期阶段的应用及进展]
Hui Wu,Ying Peng,Jian-Guo Sun et al.
Hui Wu et al.
Drug metabolism studies, including in vivo and in vitro metabolism studies, are significant in the design of candidate compounds and screening of lead compounds at drug discovery/development stages. Compared with in vivo metabolism studies,...
Gui-Dong Zhu,Yang-Xin Fu
Gui-Dong Zhu
Chemotherapy remains one of the major tools, along with surgery, radiotherapy, and more recently targeted therapy, in the war against cancer. There have appeared a plethora of highly potent cytotoxic drugs but the poor discriminability betw...
Ran Cao,Wei Li,Han-Zi Sun et al.
Ran Cao et al.
Today, the understanding of the sequence and structure of biologically relevant targets is growing rapidly and researchers from many disciplines, physics and computational science in particular, are making significant contributions to moder...
Zong-Ru Guo,Hong-Yu Zhao
Zong-Ru Guo
Drug research involves scientific discovery, technological inventions and product development. This multiple dimensional effort embodies both high risk and high reward and is considered one of the most complicated human activities. Prior to...
Yu Zhou,Lei Zhang,Zeng Li et al.
Yu Zhou et al.
Compound libraries and chemical synthesis play important roles in drug discovery and development, and efficient synthetic techniques can greatly facilitate the drug research. This review highlights the application of some efficient syntheti...
[Epigenetic mechanisms of Alzheimer's disease and related drug research] [0.03%]
阿尔茨海默病表观遗传机制及药物研究进展
Hui-Cui Gong,Yun-Liang Wang,Hong-Wei Wang
Hui-Cui Gong
Alzheimer's disease (AD) is a neurodegenerative disorder characteristic of neurons reducing, senile plaques, neurofibrillary tangles and so on, and the most common cause of dementia among the elderly. Many efforts have been made to understa...
[Recent progress in development of antibiotics against Gram-negative bacteria] [0.03%]
抗革兰氏阴性菌抗生素研究进展
Ze-Qi Xu,Ze-Yu Xu
Ze-Qi Xu
Multidrug-resistant (MDR) bacterial infections, especially those caused by Gram-negative pathogens, have emerged to be one of the world's greatest health threats. However, not only have recent decades shown a steady decline in the number of...
[Progress in anti-cancer research of American ginseng: with an example of colorectal cancer] [0.03%]
美国人参抗肿瘤研究进展：以结直肠癌为例
Chun-Hao Yu,Chong-Zhi Wang,Chun-Su Yuan
Chun-Hao Yu
Cancer is a group of various diseases, all of which involve unregulated cell growth. Many currently used chemotherapeutic drugs are derived from botanicals. Thus, searching botanical sources for novel oncology medications, including identif...
[Progress in the study of BLyS and APRIL on regulating T cell responses in rheumatoid arthritis] [0.03%]
BLyS和APRIL调节类风湿关节炎T细胞应答的研究进展
Yan Chang,Wei Wei
Yan Chang
B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation. However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmu...
Cai-Xia Zhang,Hong-Wei He,Rong-Guang Shao
Cai-Xia Zhang
Sphingolipids as an important regulator play a critical role in the cell biological functions. Among them, ceramide (Cer) and sphingosine (Sph) induce apoptosis and inhibit cell proliferation; on the contrary sphingosine 1-phosphate (S1P) p...