In vivo effect of triptolide combined with glycyrrhetinic acid on rat cytochrome P450 enzymes [0.03%]
雷公藤内酯醇联合甘草酸对大鼠细胞色素P450酶的体内效应研究
Feng-Mei Han,Zhi-Hong Peng,Jun-Jun Wang et al.
Feng-Mei Han et al.
Triptolide (TP) is a major active component in Tripterygium root, but its therapeutic window was very narrow due to its severe multi-organ toxicity. In this work, the effect of TP combined with glycyrrhetic acid (GA) on mRNA expression and ...
[Effects of six kinds of Chinese herb extracts on the activities of rat liver microsomes in vitro] [0.03%]
六种中药提取物对大鼠肝微粒体酶活性的体外影响研究
Yun-Feng Bi,Hong-Bin Zhu,Jun-Peng Xing et al.
Yun-Feng Bi et al.
Effects of six kinds of Chinese herb extracts, including Folium Crataegi extract, Herba Epimedii extract, Folium Acanthopanacis Senticosi extract, Trifolium pratense L. extract, Folium Ginkgo extract and Radix Puerariae extract, on the acti...
Jing Li,De-Quan Yu
Jing Li
Two novel isocoumarins, erigeronone C (1) and D (2), were isolated from the ethanol extract of the whole plant of Erigeron breviscapus (Vant.) Hand.-Mazz (Compositae). Their structures were respectively elucidated as 8, 9-dihydroxypyrano [3...
Qiang Wang,Er-Wei Liu,Li-Feng Han et al.
Qiang Wang et al.
To study the chemical constituents of Dipsacus asper, chromatographic methods such as D101 macroporous resin, silica gel, octadecylsilyl (ODS) column chromatographic techniques and preparative HPLC were used, and five compounds were isolate...
[Synthesis and antitumor activity of novel tetrahydro-beta-carboline derivatives as KSP inhibitors] [0.03%]
新型tetrahydro-β-咔啉衍生物的合成及其作为KSP抑制剂的抗肿瘤活性研究
Xiu-Qin Ruan,Ming Chen,Wu-Tong Wu et al.
Xiu-Qin Ruan et al.
Inhibitors of kinesin spindle protein (KSP) are a promising class of anticancer agents that cause mitotic arrest and induce apoptosis of tumor cells. A series of novel tetrahydro-beta-carboline derivatives were synthesized as kinesin spindl...
[S632A3 promotes LPS-induced IFN-beta production through inhibiting the activation of GSK-3beta] [0.03%]
[S632A3通过抑制GSK-3β活化促进LPS诱导的IFN-β产生]
Na Zhang,Xin Yang,Rong Xu et al.
Na Zhang et al.
LPS stimulation of macrophages production of IFN-beta plays a key role in innate immunity defending the microbial invasion. In this study, the effect of S632A3 promoting LPS-induced IFN-beta production and the underlying mechanism were inve...
[Expression of recombinant human kallistatin in Pichia pastoris by high density cell culture, and its purification and characterization] [0.03%]
毕赤酵母高密度发酵表达人重组蛋白kallikrein抑制因子及其纯化和鉴定
Qian Zhang,Yong-Mei Xing,Jia Liu et al.
Qian Zhang et al.
Kallistatin (Kal) is a negative acute phase endogenous protein which can inhibit tumor angiogenesis, growth and metastasis effectively. To express and purify recombinant human kallistatin (rHKal), and characterize its biological activity, P...
Jing-Yuan Song,Hong-Mei Luo,Chun-Fang Li et al.
Jing-Yuan Song et al.
Research on medicinal model organism is one of the core technologies to promote the modernization of traditional Chinese medicine (TCM). The research progress of Salvia miltiorrhiza as medicinal model plant is summarized in this paper. The ...
[Research progress in co-delivery of gene and chemotherapy drugs with nanocarriers for cancer therapy] [0.03%]
纳米载体联合输送基因和化疗药物的抗肿瘤研究进展
Wei-Guang Chen,Shi-Bin Wang
Wei-Guang Chen
Current trends in nanotechnology and RNA interference technology have made the application of nanocarriers (NCS) as a novel gene and drug delivery systems very promising for the field of multidrug resistance (MDR) cancer treatment. Co-deliv...
[Clinical pharmacokinetics of small molecule tyrosine kinase inhibitors] [0.03%]
小分子酪氨酸激酶抑制剂的临床药代动力学特征
Jue-Fang Ding,Da-Fang Zhong
Jue-Fang Ding
Human protein tyrosine kinases play an essential role in carcinogenesis and have been recognized as promising drug targets. By the end of 2012, eight small molecule tyrosine kinase inhibitors (TKIs) have been approved by State Food and Drug...