[Research progress of gene recombinant mesenchymal stem cells as tumor targeting delivery vehicles] [0.03%]
基因重组间充质干细胞作为肿瘤靶向递送载体的研究进展
Tian-Yuan Zhang,Yu-Lan Hu,Wen-Quan Liang et al.
Tian-Yuan Zhang et al.
The applications of targeting gene delivery systems in tumor therapy have attracted extensive attention of researchers in recent years, as they can selectively deliver the therapeutic gene to tumor sites, improve the success rate of gene th...
Jie Lian,Jiang Wang,Hai-Feng Sun et al.
Jie Lian et al.
The methyl group plays an important role in the rational drug design. Introducing methyl into small molecules has become an important strategy of lead compound optimization. The application of methyl in drug design is reviewed in this paper...
Gui-Bin Wang,Chuan-Jiang Zhu
Gui-Bin Wang
Tobacco smoking is a global healthcare problem that poses a substantial and costly health burden. Nicotine is the major constituent responsible for the addiction to tobacco. Current strategies helping tobacco smokers have limited utility in...
[Advance in the research on P2X7 and inflammatory respiratory diseases] [0.03%]
P2X7受体与炎症性呼吸系统疾病的研究进展
Shu-Hua Cao,Shao-Peng Yuan,Qi Hou
Shu-Hua Cao
P2X7 is the most important subtype of the ATP receptors known so far. Recent investigations showed that the downstream signaling pathway of P2X7 is coupled with several key inflammatory molecules including IL-1beta and IL-18, this suggests ...
[Oil of Piper longum unsaponifiable matter prevents cholesterol gallstone formation] [0.03%]
长胡椒不皂化物油预防胆固醇胆结石形成
Shuang Xu,Jin-Feng Hu,Shi-Feng Chu et al.
Shuang Xu et al.
To observe the effect of various doses of oil of Piper longum unsaponifiable matter (OPUM) to cholesterol gallstones in experimental mice. C57BL/6 mice (n = 60) were randomly divided into 6 groups: control group, model group, OPUM (15, 30 a...
[Construction and tobacco transformation of COR and BBE genes hairpin RNA vector of Papaver somniferum] [0.03%]
[药用罂粟COR和BBE基因发卡结构RNA反义构建及烟草转化]
Yan-Mei Lu,Jin-Wen Zhang,Yu-Jie Wei et al.
Yan-Mei Lu et al.
The gene expressions of codeinone reductase (COR) and berberine bridge enzyme (BBE) in Papaver somniferum were blocked by RNA hairpin of RNA interference (RNAi). The complete sequences of COR and BBE genes were cloned by reverse transcripti...
[Expression of subtilisin-like protease gene from Hirsutella sinensis before and after infecting Hepialus gonggaensis] [0.03%]
冬虫夏草菌素B基因在感染寄主前后表达量的变化
Zeng-Hui Lu,Ping Shi,Shi-Jiang Chen
Zeng-Hui Lu
To address the role of Pr1 gene in the process of Hirsutella sinensis infecting Hepialus gonggaensis, differential expression of subtilisin-like protease gene was detected. In the present study, Pr1 gene analogues from H. sinensis were obta...
[Real-time UV imaging of chloramphenicol intrinsic dissolution characteristics from ophthalmic in situ gel] [0.03%]
[实时UV成像技术在眼部原位凝胶中氯霉素固有溶出特性研究中的应用]
Jian-Xiu Chen,Zhen Guo,Hai-Yan Li et al.
Jian-Xiu Chen et al.
In this paper, chloramphenicol was selected as a model drug to prepare in situ gels. The intrinsic dissolution rate of chloramphenicol from in situ gel was evaluated using the surface dissolution imaging system. The results indicated that i...
[Powder modification technology used for the preparation of the hydrophilic decoction pieces of indigo naturalis and the modification principle] [0.03%]
一种雄黄饮片增水浸提粉体改性技术及其改造原理研究
Ding-Kun Zhang,Jun-Zhi Lin,Jian-Yun Liu et al.
Ding-Kun Zhang et al.
The hydrophilicity of the normal decoction pieces (NDP) of Indigo Naturalis is not good, therefore, it is not suit for decoctions. In this paper, powder modification technology is used and some NDP and alcohol are ground together in the vib...
[Anti-tumor activity of folate receptor targeting docetaxel-loaded membrane-modified liposomes] [0.03%]
叶酸受体靶向多西他赛载药膜修饰脂质体的抗肿瘤活性研究
Xiang Li,Jing Zhang,Dong-Kai Wang et al.
Xiang Li et al.
The anti-tumor activity of folate receptor targeting docetaxel-loaded membrane-modified liposomes (FA-PDCT-L) was investigated in vitro and in vivo. FA-PDCT-L was prepared by organic solvent injection method. Transmission electron microscop...