Fan Zhang,Li-Feng Han,Gui-Xiang Pan et al.
Fan Zhang et al.
A new phenolic amide glycoside, cimicifugamide A (1) along with four known compounds, trans-feruloyl tyramine 4-O-beta-D-glucopyranoside (2), (+)-isolariciresinol 3-O-beta-D-glucopyranoside (3), cimidahurine (4), and 24-epi-7, 8-didehydroci...
[Synthesis and biological evaluation of diarylamines with antitumor activity] [0.03%]
[具有抗肿瘤活性的 Diarylamine 的合成及生物评价]
Sheng-Biao Wang,Xiao-Feng Wang,Lan Xie
Sheng-Biao Wang
By structural modifications of our previous leads 1-3, 18 diarylamines were designed, synthesized and evaluated with a human tumor cell line panel, including A549, DU145, KB, and KB-vin cell lines, resulting in the discovery of new antitumo...
[Design, synthesis and biological evaluation of novel diaryl ethers bearing a pyrimidine motif as human Pin1 inhibitors] [0.03%]
新型二芳基醚类皮明啶衍生物的设计、合成及生物学评价（人Pin1抑制剂）
Yue-Yue Xi,Jing Jin,Yan Sun et al.
Yue-Yue Xi et al.
Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) belongs to peptidyl-prolyl cis-trans isomerase (PPIase) and is a novel promising anticancer target. Based on the lead structure of benzophenone, a series of novel diarylether der...
[Design, synthesis and activities of novel benzothiazole derivatives containing arylpiperazine] [0.03%]
新型苯并噻唑类含芳基哌嗪衍生物的设计、合成及活性研究
Wen-Hu Liu,Jin-Xia Chang,Yi Liu et al.
Wen-Hu Liu et al.
Twenty-four novel benzothiazole derivatives containing arylpiperazine were designed and synthesized by bioisosterism principle. Anti-proliferative effect of these synthesized compounds against four cancer cell and two normal cell lines were...
[Protection of Grateloupia filicina polysaccharide against hepatotoxicity induced by Dioscorea bulbifera L] [0.03%]
Grateloupia filicina 多糖对Dioscorea bulbifera L诱导的肝毒性保护作用研究
Yi-Bo Ma,Li-Li Ji,Shun-Chun Wang et al.
Yi-Bo Ma et al.
The present study was designed to observe the protection of Grateloupia filicina polysaccharide (GFP) against hepatotoxicity induced by Dioscorea bulbifera L in mice and its underlying mechanism. GFP was intragastrically (ig) given to mice ...
[Salidroside via ERK1/2 and PI3K/AKT/mTOR signal pathway induces mouse bone marrow mesenchymal stem cells differentiation into neural cells] [0.03%]
牻牛儿醇诱导骨髓间充质干细胞分化成神经细胞涉及erk1/2和pi3k/akt/mtor信号通路
Ya-Nan Chen,Hui Liu,Hong-Bin Zhao et al.
Ya-Nan Chen et al.
To investigate the role of the extracellular signal-regulated kinase (ERK1/2) and PI3K/AKT/ mTOR signal pathway inducing bone marrow mesenchymal stem cells (BMSCs) differentiation into neural cells, mouse bone marrow-derived mesenchymal ste...
[Effect of xuebijing oral effervescent tablet on endotoxin induced fever and disseminated intravascular coagulation rabbit model] [0.03%]
血必净注射液对内毒素致兔发热及弥漫性血管内凝血模型的影响
Shan-Shan Guo,Ying-Jie Gao,Xue-Chuan Tian et al.
Shan-Shan Guo et al.
In order to discover the mechanism of Xuebijing oral effervescent tablet (XBJOET) to treat infectious diseases, the effect of XBJOET on endotoxin induced rabbit fever and disseminated intravascular coagulation (DIC) was investigated. Auricl...
Endogenous cystathionine-gamma-lyase/hydrogen sulfide pathway regulates apoptosis of HepG2 cells [0.03%]
内源性胱硫醚-γ-裂解酶/硫化氢通路调节HepG2细胞凋亡
Tian-Xiao Wang,Xiao-Yan Shi,Ying-Hua Liu
Tian-Xiao Wang
This study is to investigate the role of endogenous CSE/H2S in regulating apoptosis of HepG2 cells. MTT and Trypan blue assay were performed to determine the effect of CSE inhibitor PAG and CSE siRNA on proliferation of HepG2. Production of...
[Valibose, an alpha-glucosidase inhibitor, ameliorates the metabolic disorder of glucose and lipids and the nephropathy in streptozotocin-induced diabetic rats] [0.03%]
糖苷酶抑制剂瓦利波塞改善链尿佐菌素诱导的糖尿病大鼠糖脂代谢紊乱及肾病病理损伤的作用研究
Quan Liu,Shuai-Nan Liu,Su-Juan Sun et al.
Quan Liu et al.
This study is to evaluate the anti-diabetic effects of the alpha-glucosidase inhibitor valibose in a streptozotocin (STZ)-induced type 1 diabetes rat model. Diabetes was induced by a single dose of STZ (58 mg x kg(-1), ip) in SD rats, rats ...
[Mifepristone repairs alteration of learning and memory abilities in rat model of depression] [0.03%]
米非司酮修复抑郁症大鼠模型学习记忆能力损伤作用的研究
Jing Li,Jian-Dong Sun,Yan Liu et al.
Jing Li et al.
This study is to investigate the amelioration effect of glucocorticoid receptor (GR) antagonist mifepristone on the changes of learning and memory abilities in rat model of depression. In the present study, a 35-day rat chronic unpredictabl...