[Protective effects of da chai hu granules (DCHKL) against alloxan (AXN)-induced rat pancreatic islets damage] [0.03%]
大柴胡颗粒对alloxan致胰岛损伤的保护作用研究
Wei Li,Liang-liang Cai,Hui-qin Xu et al.
Wei Li et al.
The protective effects of Da Chai Hu Granules (DCHKL) on islet cells which were incubated with 4 mmol x L(-1) alloxan (AXN) were studied. The viability of islet cells were measured with MTT. Insulin released into medium and in islets was de...
[Tanshinone IIA protects against triptolide-induced liver injury via Nrf2/ARE activation] [0.03%]
丹参酮ⅡA通过Nrf2/ARE激活保护三氧化二麟致肝损伤作用研究
Cui-wen Guan,Jing Jin,Jia Li et al.
Cui-wen Guan et al.
The aim of this study is to investigate the protection effect of tanshinone IIA (Tan) against triptolide (TP)-induced liver injury and the mechanisms involved. Acute liver injury was induced by intraperitoneal injection of TP (1 mg x kg(-1)...
[Active components of Ligustrum lucidum inhibiting hepatitis C virus replicase activity] [0.03%]
构树叶抑制丙型肝炎病毒复制的活性成分研究
Rui-na Sun,Yan-ni Zhang,Jun Wang et al.
Rui-na Sun et al.
Based on previous report that the Chinese herb Ligustrum lucidum (LL) extract directly inhibited hepatitis C virus (HCV) replicase (NS5B) activity, the active components of LL extract to inhibit HCV NS5B activity and their inhibition mode w...
[Application of NMR technique in the discovery and pharmacological studies of active substances from natural products] [0.03%]
[NMR技术在天然产物中活性成分发现及药理研究中的应用]
Zhao-xia Miao,Ying-hong Wang
Zhao-xia Miao
The application of HPLC-NMR-MS hyphenated technique in the structural identification of trace substances from complex mixtures and the identification of endogenous and exogenous substances in the establishment process of metabolic profiling...
Li-peng Qiu,Miao-miao Long,Da-wei Chen
Li-peng Qiu
Hyaluronic acid (HA) as anticancer drug carrier has become the new hot point in the field of tumor-targeted drugs delivery system in recent years. Tumor therapeutic agents could be transmitted into cells because of hyaluronic acid innate ab...
[Halogenated natural products from the marine-derived actinobacteria and their halogenation mechanism] [0.03%]
海洋来源链霉菌产生的卤化天然产物及其生物合成途径中的卤化机制研究进展
Yi Tan,Hong-xia Zhou,Yi-guang Wang et al.
Yi Tan et al.
In the last decade, along with the development of taxonomy research in marine-derived actinobacteria, more and more halogenated natural products were discovered from marine actinobacteria. Most of them showed good biological activity and un...
Dong-fang Jia,Dong-fang Jia,Dong-fang Jia
Dong-fang Jia
Riboswitches are cis-acting domains located in mRNA sequences that could regulate gene expression by sensing small molecules without employing protein. Most known riboswitches in bacteria have naturally evolved to bind essential metabolite ...
Yi Liu,Hai-Wei Huang,Jian-Min Wu et al.
Yi Liu et al.
This paper is to report the polymorphism of raw materials of clopidogrel bisulfate at home and abroad. By the analysis of Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (p-XRD), samples are roughly classified in...
[Peoniflorin activates Nrf2/ARE pathway to alleviate the Abeta(1-42)-induced hippocampal neuron injury in rats] [0.03%]
peoniflorin通过激活nrf2/are通路改善abeta(1-42)致大鼠海马神经元损伤的作用研究
Shu-Zhi Zhong,Shi-Ping ma,Zong-Yuan Hong
Shu-Zhi Zhong
This study was to investigate the effect of peoniflorin on the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream signal molecules in the hippocampus of Alzheimer's disease (AD) rats for exploring the mecha...
[Expression analysis of glycosyltransferase BcUGT1 from Bupleurum chinense DC. and its expression in E. coli and the target protein purification] [0.03%]
[柴胡甘草酸单糖基转移酶BcUGT1的表达分析及其在大肠杆菌中的异源表达和目的蛋白纯化]
Yun-Wen Tao,Jie-Sen Xu,Jian-He Wei et al.
Yun-Wen Tao et al.
The ORF sequence of glycosyltransferase gene BcUGT1 cloned from Bupleurum chinense DC. was analyzed and its three dimentional structure was predicted. Using qRT-PCR method, the expression characteristics of BcUGT1 after methyl jasmonate (Me...