[Construction of anti-VEGFR-2 IgG1 like human antibody and its expression in CHO-k cells] [0.03%]
抗VEGFR-2的人源IgG1型单克隆抗体构建及CHO-K细胞表达
Zhi-Ke Li,Yuan He,Juan Zhang et al.
Zhi-Ke Li et al.
Anti-angiogenesis mechanism plays a vital role in tumor targeting immunotherapy. Based on the amino acid sequence of an anti-VEGFR-2 scFv-Fc fusion antibody (AK404R-Fc), this article is aimed to generate an anti-VEGFR-2 human IgG1-like full...
Yang Liu,Chen Jiang
Yang Liu
The blood-brain barrier (BBB) exerts its central nervous system (CNS) protective function as it hinders the delivery of diagnostic and therapeutic agents to the brain. With the development of nanotechnology during the last thirty years, the...
[Lead compound optimization strategy (1)--changing metabolic pathways and optimizing metabolism stability] [0.03%]
[先导化合物优化策略（1）--改变代谢途径及优化代谢稳定性]
Jiang Wang,Hong Liu
Jiang Wang
Lead compound optimization plays an important role in new drug discovery and development. The strategies for changing metabolic pathways can modulate pharmacokinetic properties, prolong the half life, improve metabolism stability and bioava...
Cheng-Lian Deng,Jia Zou,Hai-Feng Song
Cheng-Lian Deng
As targeted drugs to B-cell malignancies, anti-CD20 monoclonal antibodies have been proved to be important in therapeutic antibody field. With three generations in more than ten years' development, the structures of these drugs have been im...
[Prosapogenin A inhibits cell growth of MCF7 via downregulating STAT3 and glycometabolism-related gene] [0.03%]
原人参二醇A通过下调STAT3和糖代谢相关基因抑制MCF-7细胞增殖
Tian-xiao Wang,Xiao-yan Shi,Yue Cong et al.
Tian-xiao Wang et al.
This study is to investigate the inhibitory effect and mechanism of prosapogenin A (PSA) on MCF7. MTT assay was performed to determine the inhibitory effect of PSA on MCF7 cells. PI/Hoechst 33342 double staining was used to detect cell apop...
[Protection effect of amentoflavone in Selaginella tamariscina against TNF-alpha-induced vascular injury of endothelial cells] [0.03%]
霍氏卷柏松脂素对TNF-α诱导的内皮细胞血管损伤的保护作用研究
Xiao-ke Zheng,Cai-xia Liu,Ying-ying Zhai et al.
Xiao-ke Zheng et al.
This study is to observe the protection effect of amentoflavone (AMT) in Selaginella tamariscina against TNF-alpha-induced vascular inflammation injury of endothelial cells. On the basis of TNF-alpha induced human umbilical vein endothelial...
[Antibody preparation and enzyme linked immunosorbent assay of Lonicera japonica phenylalnine ammonia lyase] [0.03%]
[抗菌素的制备及日本亚麻酚氨酶的酶联免疫吸附测定]
Zhou-yong Wang,Lu-qi Huang,Yuan Yuan et al.
Zhou-yong Wang et al.
The expression of phenylalnine ammonia lyase (LJPAL1) is closely related to the content of active compounds in Lonicera japonica. In this paper, a prokaryotic expression vector is constructed and LJPAL1 protein is expressed in E. coli. Thre...
[Induction of hairy roots and plantlet regeneration of Bupleurum chinense DC] [0.03%]
北沙参愈伤组织诱导及植株再生研究
Jing Sun,Jie-sen Xu,Li-zi Zhao et al.
Jing Sun et al.
In this study, the induction of hairy roots of Bupleurum chinense DC. was explored and established after experiments at different conditions: A. rhizogenes A4 was used to infect the leaves bases of B. chinense tube seedlings. The explants w...
[Transcellular process of coumarin 6 loaded PEG-PCL micelles on MDCK epithelial cells] [0.03%]
[载有 coumarin 6 的 PEG-PCL 聚合物胶束在 MDCK 上皮细胞间的穿膜过程]
Chao Yu,Bing He,Hua Zhang et al.
Chao Yu et al.
The transcellular process of coumarin 6 (C6) loaded poly(ethyl ethylene phosphate)-co-poly (epsilon-caprolactone) (PEG-PCL) micelles on Madin-Darby Canine Kidney (MDCK) epithelial cells was investigated. C6 loaded PEG-PCL micelles were prep...
[Application of factor analysis to evaluate deformation behaviors of frequently-used tablet excipients] [0.03%]
因子分析评价辅料变形行为的方法学考察及应用研究
Xiao-hai Li,Mei-dai Li,Yan Du et al.
Xiao-hai Li et al.
The present work is to investigate the correlation between physical properties and deformation behaviors of tablet excipients, and rank them according to their plastic performances during compaction. The excipients selected were compacted u...