Xin-bei Jiang,Yan-ping Li,Zhuo-rong Li
Xin-bei Jiang
Direct acting antivirals against the hepatitis C virus (HCV) have been developed and the field has been under a rapid progress in recent years. Especially, HCV inhibitors targeting nonstructural 5A (NS5A) protein are attracting much attenti...
Xiang-meng Wu,Li Sheng,Yu-fei Jia et al.
Xiang-meng Wu et al.
Human breast cancer resistance protein (BCRP), an ATP-binding cassette (ABC) efflux transporter, is mainly responsible for the transport of many endogenous and xenobiotics. BCRP is expressed in different tissues, such as placental, intestin...
Wei Xiong,Jia-jia Zhao,Ling Wang et al.
Wei Xiong et al.
Tamoxifen (TAM) is the most common nonsteroidal antiestrogen agent, which has been widely used in the prevention of recurrence of estrogen or progesterone receptor-positive breast cancer in patients. It is metabolized by cytochrome P450 oxi...
[Research progress of Gα(i/o)-coupled receptor-mediated supersensitization of adenylyl cyclase] [0.03%]
G蛋白偶联受体介导的腺苷酸环化酶超敏研究进展
Ru-qiang Xu,Val J Watts
Ru-qiang Xu
Persistent activation of most Gαi/o-coupled receptors resulted in enhanced activity of adenylyl cyclase (AC) and subsequent cyclic adenosine monophosphate (c AMP) accumulation within cells, and this phenomenon has generally been referred t...
[Molecular identification of wild populations of Dendrobium officinale based on target region amplification polymorphism] [0.03%]
基于靶标区域扩增多态性对石斛野外居群分子鉴定研究
Ling Liu,Rui Wu,Zhi-tao Niu et al.
Ling Liu et al.
In this study, TRAP molecular markers were used in identification of wild populations and hybrids of Dendrobium officinale, based on the sequences of genes encoding phosphoenolpyruvate carboxylase (PEPC), UDP-glucose pyrophosphorylase (UGP)...
[Effect of endophytic fungus on expression of key enzyme genes in pathway of salidroside biosynthesis in Rhodiola crenulata] [0.03%]
内生菌对红景天苷生物合成路径关键酶基因表达的影响
Meng-liang Wang,Ya-nan Wang,Jin-long Cui et al.
Meng-liang Wang et al.
One strain of endophytic fungus ZPRa-R-1 was obtained for the capacity of promoting production of salidroside in Rhodiola crenulata. To explain the mechanism of salidroside biosynthesis in host plant, eight housekeeping genes were evaluated...
[Overexpression of NtPMT and HnH6H changed hyoscyamine-rich Atropa belladonna to scopolamine-rich varieties] [0.03%]
[NtPMT和HnH6H过表达使颠茄从以东莨菪碱为主变为以莨菪碱为主]
Hong Quan,Ke Xia,Jun-lan Zeng et al.
Hong Quan et al.
Atropa belladonna L. is the commercial plant material for production of tropane alkaloids, including hyoscyamine and scopolamine. The wild-type Atropa belladonna is characterized by the hyoscyamine-rich chemotype, in which the hyoscyamine c...
[Preparation of liposomal artesunate dry powder inhalers and the effect on the acute lung injury of rats] [0.03%]
茋类药物肺泡吸入给药颗粒及制备工艺与其治疗急性肺损伤的效果研究
Yu-zhen Hu,Miao Li,Tong-tong Zhang et al.
Yu-zhen Hu et al.
Artesunate is one of artemisinin derivatives with anti-malarial and anti-inflammatory activities though its water solubility and bioavailability are low. Acute lung injury (ALI) is a seriously dispersive lung disease with a high mortality. ...
[Characterization of the size variants of a recombinant humanized monoclonal antibody (rhumAb1)] [0.03%]
重组人源化单克隆抗体(rhumab1)不同片段的性质研究
Jian Zhao,Wu Zhen-hua,Ming Lü et al.
Jian Zhao et al.
The composition and potency of the high temperature (40 ℃) stress induced size variants of a recombinant humanized monoclonal antibody(rhumAb1) were characterized by means of SEC-HPLC, non- reduced CE-SDS, liquid chromatography coupled wit...
[Cloning and characterization of an aromatic amino acid aminotransferase(ArAT) gene involved in tropane alkaloid biosynthesis from Hyoscyamus niger] [0.03%]
参与黑胡豆中生物碱合成的芳香族氨基酸转氨酶基因克隆及特性分析
Xiao Li,Wei Qiang,Fei Qiu et al.
Xiao Li et al.
Tropane alkaloids are anticholinergic drugs widely used clinically. Biosynthesis of tropane alkaloids in planta involves a step of transamination of phenylalanine. Based on the sequenced transcriptomes of lateral roots and leaves of Hyoscya...