Xu-jiang Yuan,Ping Zhang,Chun-yang Li et al.
Xu-jiang Yuan et al.
The butanol extract part was extracted and isolated with water, alcohol and different organic solvents from Abrus mollis leaves. 6 compounds were isolated and purified using various column chromatographies and identified with the spectral t...
[The structure-activity relationships of novel α7 nicotinic acetylcholine receptor agonists based on indolizine scaffold] [0.03%]
基于吲哚杂环的新型α7型烟碱乙酰胆碱受体激动剂的作用机制及其构效关系研究
Qing Li,Tao-yi Yang,Yu Xue et al.
Qing Li et al.
Alpha7 nicotinic acetylcholine receptor（α7 nAChR） is a ligand-gated ion channel critical for cognition, learning and memory. Deficiency of neuronal α7 nAChR has been implicated in the cognitive deficits and neuropsychiatric disorders. Chemi...
[Design, virtual screening, synthesis and anti-hepatitis B virus of oxime derivatives] [0.03%]
肟衍生物的设计、虚拟筛选、合成及抗乙肝活性研究
Xin-hua Cui,Jie Tan,Min Zhou et al.
Xin-hua Cui et al.
A series of new oxime and oxime ethers compounds were designed and virtually screened with target using the Molecular Operating Environment（MOE） software. Twelve unreported compounds including 4 oximes and 8 oxime ethers were synthesized with...
[Using the cumulative odds Logit model to explore the application of the questionnaire derived from PANSS] [0.03%]
基于PANSS量表构建累积概率Logit模型及其在精神分裂症患者中的应用分析
Shuang-min Ji,An-ning Li,Fang Dong et al.
Shuang-min Ji et al.
Currently, aripiprazole, olanzapine and risperidone are three anti-psychiatry agents commonly used in the treatment of schizophrenia. Although the efficacy of these drugs is good, schizophrenia cannot be completely cured yet. Patients need ...
[Suppression effect of Mai Shu on formation of atherosclerotic plaque of apolipoprotein E knock-out mice] [0.03%]
迈舒颗粒抑制载脂蛋白E基因敲除小鼠动脉粥样硬化斑块形成的作用效果研究
Wen-qiang Gan,Lin Gao,Yong-gang Huang et al.
Wen-qiang Gan et al.
The research aimed to investigate the suppression effect of Mai Shu which contains hawthorn, hippophae, medlar, phytosterols（β-sitosterol, stigmasterol and campesterol）, β-glucan and lycopeneon formation of atherosclerotic plaque in apolipo...
[Effect of Huangqin Tang on the function of regulatory TLR4/MyD88 signal pathway in rats with ulcerative colitis] [0.03%]
黄芩汤对溃疡性结肠炎模型大鼠调节TLR4/MyD88信号通路功能的影响
Dun-fang Wang,Yan-li Wang,Yi-wei Wang et al.
Dun-fang Wang et al.
This study was designed to investigate the effect of Huangqin Tang (HQT) on TLR4/Myd88 pathway and the downstream cytokines in rats with ulcerative colitis (UC) to explore its underlying mechanisms of action. The model of UC rats with cell ...
[Treatment of triple negative breast cancer cells with combination of mTOR1/2 inhibitor AZD8055 and MEK1/2 inhibitor PD0325901] [0.03%]
AZD8055与PD0325901联合治疗三阴性乳腺癌细胞系研究
Xi-yan Nan,Yun Wu,Li-he Zhang et al.
Xi-yan Nan et al.
MEK inhibition activates PI3K/AKT/mTOR pathway in triple negative breast cancer (TNBC) cell lines. Combination of PI3K inhibitor and MEK1/2 inhibitor is not appropriate for PI3K inhibitor insensitive TNBC cell lines. This study was designed...
[Recent advances in drug dissolution/permeation synchronous evaluation technologies based on physiological characteristics of gastrointestinal tract] [0.03%]
基于生理特征的肠道体内体外药物溶出/渗透同步评价新技术新方法研究进展
Zi-qiang Li,Xin He,Chang-xiao Liu
Zi-qiang Li
Pharmacokinetic behavior of orally administrated formulations involves dissolution and absorption in the gastrointestinal tract (GIT), which is required for the systemic effects of a drug. The dissolution and subsequent penetration through ...
[Lead compound optimization strategy(5) – reducing the hERG cardiac toxicity in drug development] [0.03%]
【候选药物优化策略（五）——降低药物开发中的hERG心脏毒性】
Sheng-bin Zhou,Jiang Wang,Hong Liu
Sheng-bin Zhou
The potassium channel encoded by the human ether-a-go-go related gene(hERG) plays a very important role in the physiological and pathological processes in human. hERG potassium channel determines the outward currents which facilitate the re...
Yuan Yin,Tian-tai Zhang,Da-yong Zhang
Yuan Yin
JAK-3, a member of the Janus kinase family, is a protein tyrosine kinase, which plays an important role in the JAK-STAT signaling pathway. Previous studies showed that regulation of JAK-3’s activity plays a crucial role in the treatment of...