Wen-chao Tu,Lin-fen Ding,Hui Yang et al.
Wen-chao Tu et al.
Five cassane diterpenes were isolated from the 95% ethanol extract of the seeds of Caesalpinia bonduc (Leguminosea) by a combination of various chromatographic methods, including silica gel, Sephadex LH-20, and semi-preparative HPLC. On the...
[The interaction between BLF and BSA and impact in interaction of RT-BSA-BLF system] [0.03%]
[BLF与BSA的相互作用及RT-BSA-BLF系统中的互作影响]
Ming Guo,Yan Wang,Xing-tao Xu
Ming Guo
The binding of rhaponticin to bovine serum albumin (BSA)-bovine lactoferrin (BLF) and the factors that affect BSA-BLF interaction have been studied by fluorescence spectroscopy and Fourier transform infrared spectroscopy. In the fluorescenc...
[Design, synthesis and structure-activity relationship studies of human dihydroorotate dehydrogenase inhibitors] [0.03%]
[人二氢乳清酸脱氢酶抑制剂的设计、合成及构效关系研究]
Ying-hui Gong,Li Liu,Tian-tian Qi et al.
Ying-hui Gong et al.
In this study, 1-(3-(4-chlorophenyl)-5-methylthio-1H-1,2,4-triazol-1-yl)-butan-1-one discovered previously in our lab was selected as a inhibitor of human dihydroorotate dehydrogenase ( HsDHODH) for structural optimization. The co-crystal o...
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency] [0.03%]
肾阳虚郁抑模型大鼠肝药酶的变化研究
Shu-fen He,Wen-zheng Ju,Hao-bin Hu et al.
Shu-fen He et al.
This study was designed to explore the impact of depression on kidney-yang deficiency in rats. Rats were repeatedly injected with hydrocortisone for 21 days to establish the depression model with kidneyyang deficiency. Tolbutamide, chlorzox...
[Effects of metoprolol or/and pravastatin on the pharmacokinetics of metformin in rats] [0.03%]
美托洛尔和/或普伐他汀对rats灌胃给药二甲双胍药代动力学影响的的研究
Yan-rong Ma,Yan-fang Wu,Ying-qin Duan et al.
Yan-rong Ma et al.
This study investigates the effects of metoprolol (METO) or/and pravastatin (PRAV) on the pharmacokinetics of metformin (METF) in rats. Twenty-eight male SD rats were divided into METF group, METF+METO group, METF+PRAV group and METF+METO+P...
[Comparative study of the corticosterone and glutamate induced PC12 cells depression model by 1H NMR metabolomics] [0.03%]
[~(1)H-NMR代谢组学建立并比较PC12细胞皮质酮和谷氨酸损伤模型]
Xiao-yan He,Jian-li Chen,Huan Xiang et al.
Xiao-yan He et al.
This study was designed to analyze the change of metabolites in the PC12 cells and its medium induced by corticosterone (CORT) and glutamate (Glu) by proton nuclear magnetic resonance ( 1H NMR) metabolomics. The multivariate statistical ana...
Comparative Study
Yao xue xue bao = Acta pharmaceutica Sinica. 2017 Feb;52(2):245-52. DOI: 2017
[Prevention of abdominal adhesions in rats by rhynchophylline through inhibition of Smad singnaling pathway] [0.03%]
异花蛇葡萄素通过抑制Smad信号途径防治大鼠肠粘连的研究
Yu Song,Hui Zhang,Rui-li Liu et al.
Yu Song et al.
Postoperative intra-abdominal adhesion is one of the most common complications in the postoperative period. Current remedies are very ineffective to prevent the pathological outcomes except steroid hormones. Rhynchophylline is deemed as a p...
[Antidepressant activity of flavonoid ethanol extract of Abelmoschus manihot corolla with BDNF up-regulation in the hippocampus] [0.03%]
ABelmoschus manihot花冠黄酮乙醇提取物的抗抑郁作用及其对海马BDNF的影响
Hong-die Cai,Wei-wei Tao,Shu-lan Su et al.
Hong-die Cai et al.
Abelmoschus manihot (L.) Medic., a folk herbal medicine in China, is a flowering plant belonging to Abelmoschus L. genus and Malvaceae family, which has been reported with an antidepressant activity. The study was designed to isolate flavon...
[Interaction between endophytes and host plant and the role of endophytes in genuineness analysis of medicinal plant] [0.03%]
内生菌与寄主药用植物的互作及其在鉴定当归真伪品中的作用
Jin-long Cui,Shun-xing Guo,Pei-gen Xiao
Jin-long Cui
Research of plant development and metabolism has drawn lots of attention with the fast development of science of mycorrhizal biology, molecular biology and metabonomics technology. It has become one of hot fields in the study of endophytes ...
[Recent progress of reactive oxygen species-responsive drug delivery systems] [0.03%]
近年响应型ROS药物递送系统研究进展
Guang-zhao Lu,Cheng Hou,Yan-qiang Zhong et al.
Guang-zhao Lu et al.