[The swelling behavior of choline fenofibrate hydrogel matrix tablets using dynamic image analysis] [0.03%]
动态图像分析法评价氯苯降脂片凝胶骨架片溶胀行为的研究
Zhen-yun Liu,Wan-zeng Liu,He-ran Li et al.
Zhen-yun Liu et al.
The purpose of this study is to investigate the effects of formulation on the swelling behavior of choline fenofibrate hydrogel matrix tablets and reveal the relation between swelling property and release profile using dynamic image analysi...
[Simultaneous determination of 7 benzodiazepines in human plasma by UHPLC-MS/MS] [0.03%]
高效液相色谱-质谱法同时测定人血浆中7种苯二氮卓类药物
Hong-yan Yu,Guo-ru Liu,Yu-jing Cui et al.
Hong-yan Yu et al.
The study was designed to develop the method for determination of 7 benzodiazepines concentration in human plasma. UHPLC-MS/MS was adopted to analyze plasma with protein precipitated by acetonitrile. Citalopram was used as an internal stand...
[Crystal structure and crystal form stability of trelagliptin succinate] [0.03%]
[trelagliptin琥珀酸盐的晶体结构及其晶型稳定性]
Jia-li Ye,Xin-bo Zhou,Su-xiang Wu et al.
Jia-li Ye et al.
In order to investigate trelagliptin succinate’s stability in solution, recrystallization and suspension methods in polar solvent (mainly in water and 95% alcohol) were used to study the crystal form transformation of trelagliptin succinat...
[Rapid characterization of constituents absorbed into blood after oral administration of steroidal saponins from Radix Ophiopogonis using UHPLC-LTQ-Orbitrap MS coupled with higher energy collision induced dissociation] [0.03%]
[利用UHPLC-LTQ-Orbitrap与高效碰撞诱导解离技术表征口服麦冬甾体皂苷后快速进入血液中的成分]
Ying Liu,Wei Cai,Ning Li et al.
Ying Liu et al.
The method of UHPLC-LTQ-Orbitrap mass spectrometry coupled with higher energy collision dissociation (HCD) was established to rapidly analyze the constituents absorbed into blood after oral administration of steroidal saponins from Radix Op...
Hang-qing Cui,Cai-ying Peng,Ying-zheng Huang et al.
Hang-qing Cui et al.
We investigated the chemical constituents of the leaves of Psidum littorale, which include 16 flavonoids, including seven flavonols, six flavonoid glycosides and three flavonones. The compounds were isolated by silica gel column chromatogra...
[Synthesis and anti-tumor activity of novel histone deacetylase inhibitors based on dihydropyridin-2-one scaffold] [0.03%]
基于二氢吡啶酮结构的组蛋白去乙酰化酶抑制剂的设计合成及体外抗肿瘤活性研究
Jia-qing Li,Xiao Han
Jia-qing Li
To discover novel dihydropyridin-2-one derivatives with higher HDAC inhibitory activity and subtype selectivity, twenty-seven dihydropyridin-2-one derivatives containing triazole unit were synthesized via click chemistry. The structures of ...
[Network pharmacology-based study on mechanisms of warming channel and relieving stagnation effects of Cinnamomum cassia Presl] [0.03%]
基于网络药理学的肉桂温通作用机制研究
Hai-dong Mu,Peng-fei Tu,Yong Jiang
Hai-dong Mu
The network pharmacology gradually expands its applications to the drug development and mechanism research. The present work aims to predict the targets and the mechanisms of "warming channel and relieving stagnation" effects of Cinnamomum ...
[Salvianolic acid A alleviate the brain damage in rats after cerebral ischemia-reperfusion through Nrf2/HO-1 pathway] [0.03%]
天胡考素A通过Nrf2/HO-1信号途径减轻大鼠脑缺血再灌注损伤的作用及机制研究
Wen Zhang,Jun-ke Song,Rong Yan et al.
Wen Zhang et al.
The aim of present study is to investigate the protective effects and mechanism of salvianolic acid A (SAA) on cerebral ischemia-reperfusion injury in rats. The model was established with middle cerebral artery occlusion and reperfusion (MC...
[Inhibitory effect of oleanolic acid on inflammatory response in IL-1β-stimulated human synovial sarcoma SW982 cells] [0.03%]
乌索酸对IL-1β诱导的人滑膜肉瘤SW982细胞炎症反应的抑制作用
Jun-jiang Lian,Bin-feng Cheng,Yao-xin Gao et al.
Jun-jiang Lian et al.
To study the role of oleanolic acid on interleukin (IL)-1β-stimulated expression of inflammatory cytokines, and to explore its anti-inflammatory mechanism in SW982 cells, the toxicity of oleanolic acid on SW982 cells was detected by MTT; e...
[The anti-HIV-1 activities of benzophenones non-nucleoside reverse transcriptase inhibitors in vitro] [0.03%]
茋类化合物的抗HIV-1活性及作用机制研究
Ping Wang,Gao-hong Zhang,Si-ying Xiang et al.
Ping Wang et al.
To evaluate the anti-HIV-1 activities of 5 benzophenones non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as DY1203, DY1204, DY1119, DY1208 and DY1209 in vitro, the cytotoxicity of 5 compounds were tested on C8166, MT-4, H9 and...