[Apoptosis of human hepatocellular carcinoma HepG-2 cells upon inhibition of STAT3 by 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle] [0.03%]
纳米载5，2’，4’-三羟基-6，7，5’-三甲氧基黄酮诱导人肝癌HepG-2细胞凋亡及其对STAT3信号通路的影响
Bin Xiao,Xuan Zhang,Mei-lan Zhang et al.
Bin Xiao et al.
This study was designed to investigate the mechanism of 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle (TTF1-NP) in the induction of apoptosis of human hepatocellular carcinoma HepG-2 cells. MTT assay, immunocytochemical stain...
Xin-yue Ge,Yong-mei Mo,Li Pan et al.
Xin-yue Ge et al.
β2-Adrenoceptor agonists are highly effective bronchodilators and are widely used in the treatment of both chronic obstructive pulmonary disease (COPD) and asthma. In the last 15 years, there has been great interest within the pharmaceutic...
[Operational models of allosteric modulation of G protein-coupled receptors] [0.03%]
[G蛋白偶联受体变构调节的操作模型]
Hao Gong,Shuo Zhang,Richard Dequan Ye
Hao Gong
Since the Monod-Wyman-Changeux (MWC) model was initially proposed to explain the allosteric interactions between proteins and their ligands 50 years ago, there have been various models and hypotheses such as the induced-fit model on the int...
[The drug development based on sphingosine-1-phosphate signaling pathway] [0.03%]
基于鞘氨醇-1-磷酸信号通路的药物开发研究进展
Jie Bai,Jin-ping Hu
Jie Bai
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid produced by the metabolism of sphingomyelin, regulates cell proliferation, migration, survival and cell-cell contacts. The sphingosine-1- phosphate signaling pathway can regulate the t...
Fei-pu Yang,Yang He,Zhen Wang et al.
Fei-pu Yang et al.
Epidemiology indicates that schizophrenia affects approximately 8‰ of the world’s population. The atypical (second and third generation) antipsychotics generally endowed with D(2)/5-HT(2A) receptors antagonism properties are commonly used...
[Cloning and protein expression of sterol-C-24-methyl transferase 2 in Tripterygium wilfordii] [0.03%]
防己氨酸甲基转移酶TwSMT2的克隆及可溶性表达
Hong-yu Guan,Ping Su,Yu-jun Zhao et al.
Hong-yu Guan et al.
24-Alkyl sterols are the major players in the control of membrane component and plant growth. In this paper, we cloned an important rate-limiting enzyme: sterol-C-24-methyl transferase (SMT) in the sterol biosynthetic pathway according to t...
[Cloning and protein expression of sterol-C-24-methyl transferase 2 in Tripterygium wilfordii] [0.03%]
Woodwardia uniglandulosa春季和秋季藻类的比较研究
Hong-yu Guan,Ping Su,Yu-jun Zhao et al.
Hong-yu Guan et al.
24-Alkyl sterols are the major players in the control of membrane component and plant growth. In this paper, we cloned an important rate-limiting enzyme: sterol-C-24-methyl transferase (SMT) in the sterol biosynthetic pathway according to t...
[Molecular cloning and functional characterization of the gene encoding hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase gene from Artemisia annua L] [0.03%]
牻牛儿牻牛儿基焦磷酸还原酶基因的克隆及功能鉴定
Fang Cao,Jing Xia,Yu-pei Chen et al.
Fang Cao et al.
Artemisinin is the first choice for malaria treatment. The plastidial MEP pathway provides 5-carbon precursors (IPP and its isomer DMAPP) for the biosynthesis of isoprenoid (including artemisinin). Hydroxy-2-methyl-2-(E)-butenyl 4-diphospha...
[Identification of Bombyx Batryticatus based on DNA barcoding technology] [0.03%]
基于DNA条形码技术的冬虫夏草鉴定研究
Jing Jia,Lin-chun Shi,Hui Yao et al.
Jing Jia et al.
To identify the commercial medicinal materials of Bombyx Batryticatus, two-dimensional DNA barcode was used to construct the "Internet Plus" identification system for Chinese medicine, which should benefit the cross-platform communication o...
[Based on in vivo fluorescence imaging technology, to extablish a fluorescence modification method for amphipathic block polymers] [0.03%]
基于活体荧光成像技术的两亲性嵌段共聚物的荧光标记方法研究
Zi-hua Xia,Yi Liu,Li-ping Yu et al.
Zi-hua Xia et al.
Rhodamine B (Rh B) was used to decorate an amphipathic block polymers (β-CD-[P(AA- co-MMA)-b-PVP](4)) in this study. First, after activated by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, rhodamine B was marked with hydroxy...