[Effects of pargyline on histone methylation in promoter and enhancer regions and transcription of CYP3A4/3A7] [0.03%]
【帕吉林对CYP3A4/3A7启动子及增强子区组蛋白甲基化和转录的影响】
Hang He,Pei Wang,Shi-gang Li et al.
Hang He et al.
This study was designed to investigate effects of pargyline on histone methylation in the promoter and enhancer regions and transcription of cytochrome P450 3A4/3A7 (CYP3A4/3A7) gene. Human primary fetal liver cells were isolated, cultured ...
[Impact of a noval PPARδ agonist on blood lipids in hyperlipidemic golden hamsters] [0.03%]
新型PPARδ激动剂降低高脂血症金黄地鼠血脂水平的影响
Lu-lu Li,Jin-chao Ai,Hong-yan Li et al.
Lu-lu Li et al.
The study was designed to explore the effects of HS060098 on activation of peroxisome proliferator-activated receptors (PPARα, γ and δ) and in the down-regulation of hyperlipidemia in golden hamster. Luciferase gene reporters of PPARα, ...
[Inhibitory effect and mechanism of deoxyschizandrin on NLRP3 inflammasome] [0.03%]
脱沙苑子素通过抑制NLRP3炎性小体活化抗内皮细胞糖修饰诱导的动脉粥样硬化抗氧化应激及炎症反应机制研究
He-rong Cui,Peng-yan Li,Yu-meng Li et al.
He-rong Cui et al.
This study was conducted to investigate the inhibitory effect and the molecular mechanism of deoxyschizandrin on the activity of NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome. Bone marrow-derived macrophages were ...
Zong-ru Guo
Zong-ru Guo
Precision medicine (PM) involves the application of "omics" analysis and system biology to analyze the cause of disease at the molecular level for targeted treatments of individual patient. Based on the targeted treatment PM is closely rela...
Zuo Du,Da-wei Chen,Zhi-wei Fu et al.
Zuo Du et al.
Praeruptorin C (PC), D (PD) and E (PE) are important compounds extracted from Peucedanum praeruptorum DUNN and have been reported to exert multiple pharmacological activities. The present study is purposed to determine the inhibition of PC,...
[Design and development of fluorescent probe substrates for carboxylesterase 1 using BODIPY as the basic fluorophore] [0.03%]
以BODIPY为基础荧光团的羧酸酯酶1型荧光探针底物的设计与开发
Le-le Ding,Zhen-hao Tian,Jie Hou et al.
Le-le Ding et al.
Carboxylesterase 1 (CE1) is an important serine hydrolase in mammals, which involved in the hydrolysis of a variety of compounds (endogenous substrates like cholesterol and xenobiotic compounds like ester-contain drugs and pesticides). This...
[Regulation of P-glycoprotein gene expression by PKC/NF-κB-PXR signaling pathway] [0.03%]
PKC/NF-κB-PXR信号通路调控P-糖蛋白基因表达的作用机制研究
Yu-hua Li,Ling Huang,Xiao-hua Wei et al.
Yu-hua Li et al.
P-glycoprotein (P-gp), an ATP binding cassette protein, plays a major role in efflux transport of drugs and xenobiotics due to its abundant expression on several barriers. This study aimed to investigate the potential role of PKC/NF-κB-PXR...
Kun Han,Si-jie Lu,Su Zeng et al.
Kun Han et al.
In our preliminary studies, we observed zolmitriptan (ZOL) treatment led to induction of CYP3A2 in male not female rats. To figure out the reason is of great significance for drug-drug interactions and personalized administration. Since gro...
[Regulatory mechanisms of gut microbiota on intestinal CYP3A and P-glycoprotein in rats with dextran sulfate sodium-induced colitis] [0.03%]
[dextran硫酸钠诱导的结肠炎大鼠肠道菌群调控肠CYP3A和P-糖蛋白的机制研究]
Xue-jiao Gao,Ting Li,Bin Wei et al.
Xue-jiao Gao et al.
As important constituents of the first-line of host defense barrier, intestinal cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) play important roles in disease pathogenesis as well as drug absorption and exposure. Clinical reports and ...
Hong-ying Ma,Jing Ning,Guang-bo Ge et al.
Hong-ying Ma et al.
Cytochrome P4502J2 (CYP2J2) is widely distributed in various human tissues and takes a part in the metabolism of endogenous compounds and drugs. CYP2J2 can convert arachidonic acid (AA) to expoxyeicosatrienoic acids (EETs), which have vario...