[Determination of doxazosin enantiomers in rat plasma and investigation of their chiral inversion] [0.03%]
[地拉普嗪对映体在大鼠血浆中的测定及其拆分研究]
Ya-Qin Zhen,De-Zhi Kong,Qing Li et al.
Ya-Qin Zhen et al.
The study is to establish an HPLC method using fluorescence detector for the determination of doxazosin enantiomers and investigate their chiral inversion in vitro and in vivo. Ultron ES-OVM was taken as the chiral chromatographic column, a...
[Characterization of the primary structure of TNK-tissue plasminogen activator using LC-MS] [0.03%]
高效液相-质谱联用法测定重组抗栓酶型组织型纤溶酶原活化剂的肽图指纹图谱
Lei Tao,You-Xue Ding,Ying Guo et al.
Lei Tao et al.
The primary structure of TNK-tissue plasminogen activator (TNK-tPA) was characterized using liquid chromatography-mass spectrometry (LC-MS). Firstly, the molecular mass of deglycosylated protein was measured. Then peptide mass mapping and M...
[A new sesquiterpenoid from fungus Colletotrichum sp. and its cytotoxicity] [0.03%]
一种Colletotrichum菌的倍半萜及其细胞毒活性
Zhi-Jun Yang,Tian Yang,Min-Yu Luo et al.
Zhi-Jun Yang et al.
A novel sesquiterpenoid (1) and three known compounds identified as isoaltenuene (2), altenuene (3), and alternariol 4, 10-O-dimethyl ether (4), were isolated in our investigation of the cytotoxic constituents from solid cultures of the end...
Huan-Xin Zhao,Tian-Tian Nie,Huan-Jie Guo et al.
Huan-Xin Zhao et al.
The roots of Pittosporum glabratum Lindl. (Pittosporaceae) have been used as a folk medicine for the treatment of rheumatic arthritis, insomnia and hypertension. Only a few chemical or biological studies on P. glabratum have been reported. ...
[Design, synthesis and biological activity evaluation of adenosine analogues] [0.03%]
腺苷类似物的设计、合成及生物活性评价
Dong-Mei Wang,Xiao-Hui Liu,Hui Guo et al.
Dong-Mei Wang et al.
N6-(2-Hydroxyethyl) adenosine, HEA (1), an active ingredient isolated from cultured mycelia of cordyceps species which is a famous traditional tonic in China, showed brain protective, sedative hypnotic activity in pharmacological tests. In ...
[Design, synthesis and antitumor activity of valproic acid salicylanilide esters] [0.03%]
[valproic酸水杨酰胺酯的设计、合成及抗肿瘤活性]
Ming Yuan,Jia-Ming Li,Guang-Wei He et al.
Ming Yuan et al.
A series of valproic acid salicylanilide esters were designed and synthesized based on the principle of prodrug. The structures of the target compounds were confirmed by MS, 1H NMR and 13C NMR. Anti-tumor activities of these compounds again...
Kang-Ning Li,Jing Jin,Xiao-Guang Chen
Kang-Ning Li
Annexin A1 (ANXA1) is a kind of endogenous scaffold protein. Previous research showed that ANXA1 could increase markedly with multiple increase of drug resistance in K562/imatinib cell lines in vitro. Here the stable transfection cell strai...
[Mechanism and action characteristics studies of a quinoxalinone compound against HIV-1 replication] [0.03%]
[喹唑酮类化合物抗HIV-1复制的机制及作用特点研究]
Ming-Yu Ba,Ying-Li Cao,Bai-Ling Xu et al.
Ming-Yu Ba et al.
This study is to investigate the mechanism and action characteristics of 6-chloro-3-methyl-4-(2-methyoxycarbonylthiophene-3-sulfonyl)-3, 4-dihydroquinoxa-lin-2-(1 H)-one (XU07011) against HIV-1 replication. XU07011 anti-HIV activity was tes...
[Molecular mechanism of ophiopogonin B induced cellular autophagy of human cervical cancer HeLa cells] [0.03%]
[菝葜皂苷元B诱导人宫颈癌HeLa细胞自噬的分子机制]
Qiu-Ju Xu,Li-Li Hou,Guo-Qiang Hu et al.
Qiu-Ju Xu et al.
This study is to investigate the antitumor activity of ophiopogonin B (OP-B). MTT assay, flow cytometric analysis, acridine orange staining, Lyso-Tracker Red staining and HeLa-GFP-LC3 transfect cells assay were used to detect the proliferat...
[The activation effect of nobiletin on cystic fibrosis transmembrane conductance regulator chloride channel] [0.03%]
[nobiletin对囊性纤维化跨膜转导调节因子氯通道的激活作用]
Shuang Yang,Bo Yu,Yao-Fang Zhang et al.
Shuang Yang et al.
Aim of the present study is to investigate activation effect of nobiletin on cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity. CFTR-mediated iodide influx assay and patch-clamp tests were done on FRT cell...