G D Sidelnikov,A R Valikhov
G D Sidelnikov
Retrotransposons are the mobile part of the genetic material in mammals. Such a close proximity is a unique in its kind example of the genetic symbiosis. As a result of long-term co-evolution retroviruses purchased the actual immortality an...
Review
Voprosy onkologii. 2016;62(6):758-766. DOI: 2016
A A Bessonov,A G Iyevleva,E N Imyanitov et al.
A A Bessonov et al.
CHEK2 is classified as a moderate-penetrance gene for hereditary breast cancer (BC). In Russia, CHEK2 mutations hold second position in the list of BC-predisposing gene defects after BRCAl, and include CHEK2 1100deIC, de15395, and IVS2+lG>A...
Review
Voprosy onkologii. 2016;62(6):753-757. DOI: 2016
[Sunitinib: 10 years after approval for the therapy of metastatic renal cell carcinoma] [0.03%]
索坦治疗转移性肾细胞癌的十年历程回顾与展望
I V Tsimafeyeu
I V Tsimafeyeu
Sunitinib is one of first targeted agents and tyrosine kinase inhibitors of vascular endothelial growth factor receptor (VEGFR) that approved for therapy of metastatic renal cell carcinoma. -Moreover it is among the first compounds in oncol...
Review
Voprosy onkologii. 2016;62(6):741-752. DOI: 2016
[The role of inflammatory and anti- inflammatory factors in endometrial cancer and its types: tumor and adipose tissue] [0.03%]
炎症及抗炎因子在子宫内膜癌及其肿瘤和脂肪组织中的作用
L M Berstein
L M Berstein
An inflammation expressed in a moderate degree and hav- ing a chronic character is associated with the local changes in the tumor and adipose tissue (manifested, in particular, by lym- phocytic and macrophage infiltration) as well as with s...
Review
Voprosy onkologii. 2016;62(6):732-739. DOI: 2016
[Cardiotoxicity of trastuzumab: mechanisms of development, diagnosis, treatment] [0.03%]
曲妥珠单抗导致的心脏毒性作用：发生机制、诊断和治疗措施
A G Ovchinnikov,A V Skorobogatova,T Yu Seiniglazova et al.
A G Ovchinnikov et al.
The review discusses mechanisms of trastuzumab cardio- toxicity. There are presented risk factors of development of the left ventricular dysfunction in treatment of a drug, among which the most important are the simultaneous administration ...
Review
Voprosy onkologii. 2016;62(6):719-731. DOI: 2016
E N Suspitsyn,A P Sokolenko,E N Imyanitov
E N Suspitsyn
Whole exome sequencing (WES) has become a leading tool for genetic analysis right after its invention. This approach permits the detection of mutations spread within coding regions of the entire genome. For cancer patients WES is particular...
Review
Voprosy onkologii. 2016;62(6):713-718. DOI: 2016
[Contribution of Academician L. M. Shabad in the theory and practice of preventing cancer from exposure to carcinogenic agents (Leningrad period)] [0.03%]
[L.M.沙巴德院士关于致癌因素所致癌症预防的理论和实践贡献（列宁格勒时期）]
G B Pliss
G B Pliss
The article is devoted to the Leningrad period of activity of Academician Leon Manusovich Shabad, his contribution to the theory and practice of preventing cancer from exposure to carcinogenic agents.
Y I Pigolkin,M A Shilova,S N Zakharov et al.
Y I Pigolkin et al.
The article presents a review of references on causes of sudden death of persons suffering from oncological diseases. The paper describes the main mechanisms of sudden death of persons with cancer who are subjected to forensic-medical resea...
V A Chulkova,N G Vasilieva,O A Chernenko
V A Chulkova
Physical pain can be a major component of cancer patient’s suffering but suffering itself covers much more different sides of a human being than physical manifestations and often happens in the absence of physical pain. Suffering or total ...
E V Dorokhov,E D Isagulyan,P A Isaev et al.
E V Dorokhov et al.
The purpose of this paper is the demonstration and analysis of the effectiveness of spinal cord stimulation in treatment of chronic drug-resistant neuropathy pain in a patient with radiation-induced plexopathy. She underwent radiation thera...
Case Reports
Voprosy onkologii. 2016;62(4):524-8. DOI: 2016