Soft repression and chromatin modification by conserved transcriptional corepressors [0.03%]
保守的转录共抑制因子引起的温和型基因沉默和染色质修饰作用
David N Arnosti
David N Arnosti
Transcriptional regulation in eukaryotic cells involves the activity of multifarious DNA-binding transcription factors and recruited corepressor complexes. Together, these complexes interact with the core transcriptional machinery, chromati...
Coordination of cross-talk between metabolism and epigenetic regulation by the SIN3 complex [0.03%]
SIN3复合体介导的代谢与表观遗传调控互作协调机制研究
Imad Soukar,Anjalie Amarasinghe,Lori A Pile
Imad Soukar
Post-translational modifications of histone proteins control the expression of genes. Metabolites from central and one-carbon metabolism act as donor moieties to modify histones and regulate gene expression. Thus, histone modification and g...
Regulatory miRNAs in cancer cell recovery from therapy exposure and its implications as a novel therapeutic strategy for preventing disease recurrence [0.03%]
治疗后癌症细胞复苏的调控miRNA及其作为防止疾病复发的新疗法的意义研究
Joseph Landry,Kathryn Shows,Akash Jagdeesh et al.
Joseph Landry et al.
The desired outcome of cancer therapies is the eradication of disease. This can be achieved when therapy exposure leads to therapy-induced cancer cell death as the dominant outcome. Theoretically, a permanent therapy-induced growth arrest c...
James T Kadonaga
James T Kadonaga
Nucleosomes are intrinsically immobile, and thus, ATP-dependent chromatin remodeling factors are needed to alter nucleosomes to facilitate DNA-directed processes such as transcription. More generally, chromatin remodeling factors mediate ch...
Fuyuhiko Tamanoi,Kenichi Yoshikawa
Fuyuhiko Tamanoi
Editorial
The Enzymes. 2022:52:ix. DOI:10.1016/S1874-6047(22)00033-6 2022
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Publication of the second edition of The Enzymes series was initiated in 1959 and eight volumes were published. This chapter describes volumes 4-8. All eight volumes were edited by Paul D. Boyer, Henry Lardy and Karl Myerback. Authors and c...
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Publication of the second edition of The Enzymes series was initiated in 1959 and eight volumes were published. This chapter describes volumes 1-3. All the eight volumes were edited by Paul D. Boyer, Henry Lardy and Karl Myerback. Authors a...
The enzymes first edition [0.03%]
第一版的酶
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
The Enzymes series was initiated in 1950 with the publication of a book entitled, "The Enzymes: Chemistry and Mechanism of Action" edited by James B. Sumner and Karl Myerback. There are two parts, Part 1 and Part 2 and the book contains 78 ...
Fuyuhiko Tamanoi,Kenichi Yoshikawa
Fuyuhiko Tamanoi
Cancer is a worldwide problem afflicting 19 million people. Inhibition of DNA synthesis has been a cornerstone of anticancer therapy. A variety of chemotherapy drugs have been developed and many of these are aimed at inhibiting DNA synthesi...
Fuyuhiko Tamanoi,Kenichi Yoshikawa
Fuyuhiko Tamanoi
DNA damage and breaks are events that happen to DNA which exert a variety of influence on cell physiology including inhibition of DNA synthesis, repair response, cell cycle effect and cell death. Thus, it is important to deepened understand...