Quantitative evaluation of DNA double-strand breaks (DSBs) through single-molecule observation [0.03%]
通过单分子观察对DNA双链断裂(DSBs)进行定量评估
Kenichi Yoshikawa
Kenichi Yoshikawa
By adapting the method of single molecular observation for individual DNAs, it will be shown that reliable analysis of double-strand breaks, DSBs, becomes possible for various kinds of damage sources. Single DNA above the size of several-te...
DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT) [0.03%]
硼中子捕获治疗(BNCT)诱导的DNA损伤和生物反应
Natsuko Kondo
Natsuko Kondo
Boron Neutron Capture Therapy (BNCT) is a tumor cell selective high LET (linear energy transfer) particle beam therapy. The patient is administrated a boron (10B) compound via intravenous injection or infusion, and when 10B is sufficiently ...
Yue Ma,Iwaki Akiyama
Yue Ma
Since the application of ultrasound for clinical diagnosis and therapeutic purposes has been increased rapidly, the effects of exposure to ultrasound on DNA molecules were studied. In this chapter, we introduced various effects of DNA damag...
Katsuhiko Minami,Shiori Iida,Kazuhiro Maeshima
Katsuhiko Minami
Genomic DNA is organized three-dimensionally in the nucleus as chromatin. Recent accumulating evidence has demonstrated that chromatin organizes into numerous dynamic domains in higher eukaryotic cells, which act as functional units of the ...
Yuji Hatano,Hiroaki Nakamura,Susumu Fujiwara et al.
Yuji Hatano et al.
Tritium is a radioisotope of hydrogen emitting low energy β-rays in disintegration to 3He. DNA molecules are damaged mainly by β-ray irradiation, and additional damages can be induced by break of chemical bond by nuclear transmutation to ...
Atsushi Shibata
Atsushi Shibata
A carbon ion categorized as a heavy ion particle has been used for cancer radiotherapy. High linear energy transfer (LET) carbon ion irradiation deposits energy at a high density along a particle track, generating multiple types of DNA dama...
Auger electrons and DNA double-strand breaks studied by using iodine-containing chemicals [0.03%]
使用含碘化学物质研究奥斯特电子和DNA双链断裂
Yuya Higashi,Yue Ma,Kotaro Matsumoto et al.
Yuya Higashi et al.
Irradiation of high Z elements such as iodine, gold, gadolinium with monochromatic X-rays causes photoelectric effects that include the release of Auger electrons. Decay of radioactive iodine such as I-123 and I-125 also results in multiple...
Fuyuhiko Tamanoi,Kenichi Yoshikawa
Fuyuhiko Tamanoi
DNA is under a variety of assaults. As a result, different damages accumulate on DNA. These include base changes, single-strand breaks and double-strand breaks. In this volume and also briefly in the following volume, we discuss DNA damage ...
Craig E Cameron,Jamie J Arnold,Laurie S Kaguni
Craig E Cameron
Jocelyne Piret,Guy Boivin
Jocelyne Piret
Human herpesviruses are large double-stranded DNA viruses belonging to the Herpesviridae family. The main characteristics of these viruses are their ability to establish a lifelong latency into the host with a potential to reactivate period...