DNA replication machineries: Structural insights from crystallography and electron microscopy [0.03%]
来自结晶学和电子显微镜的DNA复制机制的结构见解
Rebeca Bocanegra,María Ortíz-Rodríguez,Lyra Zumeta et al.
Rebeca Bocanegra et al.
Since the discovery of DNA as the genetic material, scientists have been investigating how the information contained in this biological polymer is transmitted from generation to generation. X-ray crystallography, and more recently, cryo-ele...
The Hsp70 and JDP proteins: Structure-function perspective on molecular chaperone activity [0.03%]
Hsp70和JDP蛋白：分子伴侣活性的结构功能视角
Szymon J Ciesielski,Cameron Young,Elena J Ciesielska et al.
Szymon J Ciesielski et al.
Proteins are the most structurally diverse cellular biomolecules that act as molecular machines driving essential activities of all living organisms. To be functional, most of the proteins need to fold into a specific three-dimensional stru...
Yuichi Matsushima
Yuichi Matsushima
Mitochondria are multifunctional organelles that play a central role in a wide range of life-sustaining tasks in eukaryotic cells, including adenosine triphosphate (ATP) production, calcium storage and coenzyme generation pathways such as i...
Batoul M Issleny,Rama Jamjoum,Saurav Majumder et al.
Batoul M Issleny et al.
In late November 2019, Prof. Lina M. Obeid passed away from cancer, a disease she spent her life researching and studying its intricate molecular underpinnings. Along with her husband, Prof. Yusuf A. Hannun, Obeid laid down the foundations ...
Mårten Wikström,Cristina Pecorilla,Vivek Sharma
Mårten Wikström
We present a brief review of the mitochondrial respiratory chain with emphasis on complexes I, III and IV, which contribute to the generation of protonmotive force across the inner mitochondrial membrane, and drive the synthesis of ATP by t...
Mitogen-activated protein kinase (MAPK) cascades-A yeast perspective [0.03%]
mitogen活化蛋白激酶(MAPK)级联反应——酵母的视角
Lee Bardwell,Jeremy Thorner
Lee Bardwell
Discovery of the class of protein kinase now dubbed a mitogen (or messenger)-activated protein kinase (MAPK) is an illustrative example of how disparate lines of investigation can converge and reveal an enzyme family universally conserved a...
History of advances in enzyme kinetic methods: From minutes to milliseconds [0.03%]
酶动力学法检测的历史变迁：从分钟到毫秒
Kenneth A Johnson
Kenneth A Johnson
The last review on transient-state kinetic methods in The Enzymes was published three decades ago (Johnson, K.A., 1992. The Enzymes, XX, 1-61). In that review the foundations were laid out for the logic behind the design and interpretation ...
David N Arnosti,Laurie S Kaguni
David N Arnosti
Jonatan Caroli,Andrea Mattevi
Jonatan Caroli
NPAC is a transcriptional co-activator widely associated with the H3K36me3 epigenetic marks present in the gene bodies. NPAC plays a fundamental role in RNA polymerase progression, and its depletion downregulates gene transcription. In this...
Jonathan Lenz,Alexander Brehm
Jonathan Lenz
The Nucleosome Remodeling and Deacetylating Complex (NuRD) is ubiquitously expressed in all metazoans. It combines nucleosome remodeling and histone deacetylating activities to generate inaccessible chromatin structures and to repress gene ...