Regulatory miRNAs in cancer cell recovery from therapy exposure and its implications as a novel therapeutic strategy for preventing disease recurrence [0.03%]
治疗后癌症细胞复苏的调控miRNA及其作为防止疾病复发的新疗法的意义研究
Joseph Landry,Kathryn Shows,Akash Jagdeesh et al.
Joseph Landry et al.
The desired outcome of cancer therapies is the eradication of disease. This can be achieved when therapy exposure leads to therapy-induced cancer cell death as the dominant outcome. Theoretically, a permanent therapy-induced growth arrest c...
James T Kadonaga
James T Kadonaga
Nucleosomes are intrinsically immobile, and thus, ATP-dependent chromatin remodeling factors are needed to alter nucleosomes to facilitate DNA-directed processes such as transcription. More generally, chromatin remodeling factors mediate ch...
Fuyuhiko Tamanoi,Kenichi Yoshikawa
Fuyuhiko Tamanoi
Editorial
The Enzymes. 2022:52:ix. DOI:10.1016/S1874-6047(22)00033-6 2022
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Publication of the second edition of The Enzymes series was initiated in 1959 and eight volumes were published. This chapter describes volumes 4-8. All eight volumes were edited by Paul D. Boyer, Henry Lardy and Karl Myerback. Authors and c...
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Publication of the second edition of The Enzymes series was initiated in 1959 and eight volumes were published. This chapter describes volumes 1-3. All the eight volumes were edited by Paul D. Boyer, Henry Lardy and Karl Myerback. Authors a...
The enzymes first edition [0.03%]
第一版的酶
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
The Enzymes series was initiated in 1950 with the publication of a book entitled, "The Enzymes: Chemistry and Mechanism of Action" edited by James B. Sumner and Karl Myerback. There are two parts, Part 1 and Part 2 and the book contains 78 ...
Fuyuhiko Tamanoi,Kenichi Yoshikawa
Fuyuhiko Tamanoi
Cancer is a worldwide problem afflicting 19 million people. Inhibition of DNA synthesis has been a cornerstone of anticancer therapy. A variety of chemotherapy drugs have been developed and many of these are aimed at inhibiting DNA synthesi...
Fuyuhiko Tamanoi,Kenichi Yoshikawa
Fuyuhiko Tamanoi
DNA damage and breaks are events that happen to DNA which exert a variety of influence on cell physiology including inhibition of DNA synthesis, repair response, cell cycle effect and cell death. Thus, it is important to deepened understand...
Core level ionization or excitation and Auger relaxation induce clustered DNA damage [0.03%]
内壳层电离或激发及Auger弛豫诱导的DNA链簇损伤
Akinari Yokoya,Yui Obata
Akinari Yokoya
Ionizing radiation causes various types of DNA damage, such as single- (SSBs) and double-strand breaks (DSBs), nucleobase lesions, abasic sites (AP sites), and cross-linking between complementary strands of DNA or DNA and proteins. DSBs are...