Yuichi Matsushima
Yuichi Matsushima
Mitochondria are multifunctional organelles that play a central role in a wide range of life-sustaining tasks in eukaryotic cells, including adenosine triphosphate (ATP) production, calcium storage and coenzyme generation pathways such as i...
Batoul M Issleny,Rama Jamjoum,Saurav Majumder et al.
Batoul M Issleny et al.
In late November 2019, Prof. Lina M. Obeid passed away from cancer, a disease she spent her life researching and studying its intricate molecular underpinnings. Along with her husband, Prof. Yusuf A. Hannun, Obeid laid down the foundations ...
Mårten Wikström,Cristina Pecorilla,Vivek Sharma
Mårten Wikström
We present a brief review of the mitochondrial respiratory chain with emphasis on complexes I, III and IV, which contribute to the generation of protonmotive force across the inner mitochondrial membrane, and drive the synthesis of ATP by t...
Mitogen-activated protein kinase (MAPK) cascades-A yeast perspective [0.03%]
mitogen活化蛋白激酶(MAPK)级联反应——酵母的视角
Lee Bardwell,Jeremy Thorner
Lee Bardwell
Discovery of the class of protein kinase now dubbed a mitogen (or messenger)-activated protein kinase (MAPK) is an illustrative example of how disparate lines of investigation can converge and reveal an enzyme family universally conserved a...
History of advances in enzyme kinetic methods: From minutes to milliseconds [0.03%]
酶动力学法检测的历史变迁：从分钟到毫秒
Kenneth A Johnson
Kenneth A Johnson
The last review on transient-state kinetic methods in The Enzymes was published three decades ago (Johnson, K.A., 1992. The Enzymes, XX, 1-61). In that review the foundations were laid out for the logic behind the design and interpretation ...
David N Arnosti,Laurie S Kaguni
David N Arnosti
Jonatan Caroli,Andrea Mattevi
Jonatan Caroli
NPAC is a transcriptional co-activator widely associated with the H3K36me3 epigenetic marks present in the gene bodies. NPAC plays a fundamental role in RNA polymerase progression, and its depletion downregulates gene transcription. In this...
Jonathan Lenz,Alexander Brehm
Jonathan Lenz
The Nucleosome Remodeling and Deacetylating Complex (NuRD) is ubiquitously expressed in all metazoans. It combines nucleosome remodeling and histone deacetylating activities to generate inaccessible chromatin structures and to repress gene ...
Soft repression and chromatin modification by conserved transcriptional corepressors [0.03%]
保守的转录共抑制因子引起的温和型基因沉默和染色质修饰作用
David N Arnosti
David N Arnosti
Transcriptional regulation in eukaryotic cells involves the activity of multifarious DNA-binding transcription factors and recruited corepressor complexes. Together, these complexes interact with the core transcriptional machinery, chromati...
Coordination of cross-talk between metabolism and epigenetic regulation by the SIN3 complex [0.03%]
SIN3复合体介导的代谢与表观遗传调控互作协调机制研究
Imad Soukar,Anjalie Amarasinghe,Lori A Pile
Imad Soukar
Post-translational modifications of histone proteins control the expression of genes. Metabolites from central and one-carbon metabolism act as donor moieties to modify histones and regulate gene expression. Thus, histone modification and g...