Molly S Youse,Katrina J Holly,Daniel P Flaherty
Molly S Youse
Carbonic anhydrases (CAs) are ubiquitous enzymes that are found in all kingdoms of life. Though different classes of CAs vary in their roles and structures, their primary function is to catalyze the reaction between carbon dioxide and water...
Bianca Laura Bernardoni,Concettina La Motta,Simone Carradori et al.
Bianca Laura Bernardoni et al.
Infections from Helicobacter pylori (Hp) are endangering Public Health safety worldwide, due to the associated high risk of developing severe diseases, such as peptic ulcer, gastric cancer, diabetes, and cardiovascular diseases. Current the...
Fabrizio Carta
Fabrizio Carta
Non-sulfonamide chemical moieties able to inhibit the bacterial (b) expressed Carbonic Anhydrases (CAs; EC 4.2.1.1) constitute an important alternative to the prototypic modulators discussed in Chapter 6, as give access to large and variega...
Alessio Nocentini
Alessio Nocentini
The increasing prevalence of antibiotic-resistant bacteria necessitates the exploration of novel therapeutic targets. Bacterial carbonic anhydrases (CAs) have been known for decades, but only in the past ten years they have garnered signifi...
Bacterial ι-CAs [0.03%]
细菌ι-CA酶
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Recent research has identified a novel class of carbonic anhydrases (CAs), designated ι-CA, predominantly found in marine diatoms, eukaryotic algae, cyanobacteria, bacteria, and archaea genomes. This class has garnered attention owing to i...
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Bacterial carbonic anhydrases (BCAs, EC 4.2.1.1) are indispensable enzymes in microbial physiology because they facilitate the hydration of carbon dioxide (CO2) to bicarbonate ions (HCO3-) and protons (H+), which are crucial for various met...
Robert P Hausinger
Robert P Hausinger
Metalloenzymes have been detailed in The Enzymes since its inception over half a century ago. Here, I review selected metal-containing enzyme highlights from early chapters in this series and I describe advances made since those contributio...
Howard T Jacobs
Howard T Jacobs
Although recognized earlier as subcellular entities by microscopists, mitochondria have been the subject of functional studies since 1922, when their biochemical similarities with bacteria were first noted. In this overview I trace the hist...
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Since its publication in 1950, the series "The Enzymes" has been established as an important reference book for researchers and students in the field of enzymology, biochemistry and biophysics and medical research. A number of scientists ha...
Helicases required for nucleotide excision repair: structure, function and mechanism [0.03%]
核苷酸切除修复所需要的解旋酶：结构、功能与机理研究
Feng He,Marco Bravo,Li Fan
Feng He
Nucleotide excision repair (NER) is a major DNA repair pathway conserved from bacteria to humans. Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required b...