Fabrizio Carta
Fabrizio Carta
Non-sulfonamide chemical moieties able to inhibit the bacterial (b) expressed Carbonic Anhydrases (CAs; EC 4.2.1.1) constitute an important alternative to the prototypic modulators discussed in Chapter 6, as give access to large and variega...
Alessio Nocentini
Alessio Nocentini
The increasing prevalence of antibiotic-resistant bacteria necessitates the exploration of novel therapeutic targets. Bacterial carbonic anhydrases (CAs) have been known for decades, but only in the past ten years they have garnered signifi...
Bacterial ι-CAs [0.03%]
细菌ι-CA酶
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Recent research has identified a novel class of carbonic anhydrases (CAs), designated ι-CA, predominantly found in marine diatoms, eukaryotic algae, cyanobacteria, bacteria, and archaea genomes. This class has garnered attention owing to i...
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Bacterial carbonic anhydrases (BCAs, EC 4.2.1.1) are indispensable enzymes in microbial physiology because they facilitate the hydration of carbon dioxide (CO2) to bicarbonate ions (HCO3-) and protons (H+), which are crucial for various met...
Robert P Hausinger
Robert P Hausinger
Metalloenzymes have been detailed in The Enzymes since its inception over half a century ago. Here, I review selected metal-containing enzyme highlights from early chapters in this series and I describe advances made since those contributio...
Howard T Jacobs
Howard T Jacobs
Although recognized earlier as subcellular entities by microscopists, mitochondria have been the subject of functional studies since 1922, when their biochemical similarities with bacteria were first noted. In this overview I trace the hist...
Fuyuhiko Tamanoi
Fuyuhiko Tamanoi
Since its publication in 1950, the series "The Enzymes" has been established as an important reference book for researchers and students in the field of enzymology, biochemistry and biophysics and medical research. A number of scientists ha...
Helicases required for nucleotide excision repair: structure, function and mechanism [0.03%]
核苷酸切除修复所需要的解旋酶：结构、功能与机理研究
Feng He,Marco Bravo,Li Fan
Feng He
Nucleotide excision repair (NER) is a major DNA repair pathway conserved from bacteria to humans. Various DNA helicases, a group of enzymes capable of separating DNA duplex into two strands through ATP binding and hydrolysis, are required b...
DNA replication machineries: Structural insights from crystallography and electron microscopy [0.03%]
来自结晶学和电子显微镜的DNA复制机制的结构见解
Rebeca Bocanegra,María Ortíz-Rodríguez,Lyra Zumeta et al.
Rebeca Bocanegra et al.
Since the discovery of DNA as the genetic material, scientists have been investigating how the information contained in this biological polymer is transmitted from generation to generation. X-ray crystallography, and more recently, cryo-ele...
The Hsp70 and JDP proteins: Structure-function perspective on molecular chaperone activity [0.03%]
Hsp70和JDP蛋白：分子伴侣活性的结构功能视角
Szymon J Ciesielski,Cameron Young,Elena J Ciesielska et al.
Szymon J Ciesielski et al.
Proteins are the most structurally diverse cellular biomolecules that act as molecular machines driving essential activities of all living organisms. To be functional, most of the proteins need to fold into a specific three-dimensional stru...