Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Carbonic anhydrases (CAs) play an essential role in the physiology and survival of protozoan parasites. This study explores the biological functions, molecular features, and therapeutic potential of protozoan CAs, focusing on the α, β, an...
Alane Beatriz Vermelho,Felipe Raposo P Mansoldo,Veronica Silva Cardoso et al.
Alane Beatriz Vermelho et al.
Neglected tropical diseases (NTDs) such as Chagas disease and leishmaniasis represent significant public health challenges due to limited therapeutic options and the emergence of drug-resistant parasites. This chapter explores the potential...
Claudiu T Supuran,Clemente Capasso
Claudiu T Supuran
Malaria parasites belonging to the genus Plasmodium encode for a carbonic anhydrase (CA, EC 4.2.1.1) originally considered to belong to the α-class, which has been investigated starting with 2004 as a potential antimalarial target, conside...
Claudiu T Supuran,Clemente Capasso
Claudiu T Supuran
An overview of carbonic anhydrases (CAs) in fungi and protozoa is provided, emphasizing their evolutionary significance, functional diversity, and implications for human health. CAs are metalloenzymes that catalyze the reversible hydration ...
Aslınur Doğan,Suleyman Akocak
Aslınur Doğan
Tyrosinase is a crucial copper-containing enzyme involved in the production of melanin. Melasma, age spots, and freckles are examples of hyperpigmentation diseases caused by excess production of melanin. Inhibiting tyrosinase activity is a ...
Structural characterization of tyrosinases and an update on human enzymes [0.03%]
酪氨酶的结构表征及人类酶的最新研究进展
Luigi Franklin Di Costanzo
Luigi Franklin Di Costanzo
Tyrosinase, a pivotal enzyme in melanin biosynthesis, orchestrates the pigmentation process in humans, affecting skin, hair, and eye color. This chapter examines the three-dimensional structure and functional aspects of tyrosinases from var...
Samaneh Zolghadri,Ali Akbar Saboury
Samaneh Zolghadri
Tyrosinases (TYR) play a key role in melanin biosynthesis by catalyzing two reactions: monophenolase and diphenolase activities. Despite low amino acid sequence homology, TYRs from various organisms (from bacteria to humans) have similar ac...
Luigi Pisano,Martina Turco,Claudiu T Supuran
Luigi Pisano
Tyrosinase is involved in several human diseases, among which hypopigmentation and depigmentation conditions (vitiligo, idiopathic guttate hypomelanosis, pityriasis versicolor, pityriasis alba) and hyperpigmentations (melasma, lentigines, p...
Ali Irfan,Yousef A Bin Jardan,Laila Rubab et al.
Ali Irfan et al.
Bacterial tyrosinase is a copper-containing metalloenzyme with diverse physio-chemical properties, that have been identified in various bacterial strains, including actinobacteria and proteobacteria. Tyrosinases are responsible for the rate...
Alessandro Bonardi,Paola Gratteri
Alessandro Bonardi
Computational studies have significantly advanced the understanding of tyrosinase (TYR) function, mechanism, and inhibition, accelerating the development of more effective and selective inhibitors. This chapter provides an overview of in si...