Overview on tyrosinases: Genetics, molecular biology, phylogenetic relationship [0.03%]
酪氨酸酶概论：遗传学、分子生物学及亲缘关系
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Tyrosinases (TYRs) are enzymes found in various organisms that are crucial for melanin biosynthesis, coloration, and UV protection. They play vital roles in insect cuticle sclerotization, mollusk shell formation, fungal and bacterial pigmen...
Andrea Angeli
Andrea Angeli
Carbonic anhydrases (CAs) are a ubiquitous family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate and protons, playing pivotal roles in a variety of biological processes including respiration, ...
Marta Ferraroni
Marta Ferraroni
β-Carbonic anhydrases (β-CA; EC 4.2.1.1) are widespread zinc metalloenzymes which catalyze the interconversion of carbon dioxide and bicarbonate. They have been isolated in many pathogenic and non-pathogenic bacteria where they are involv...
Claudiu T Supuran
Claudiu T Supuran
Acetazolamide, methazolamide, ethoxzolamide and dorzolamide, classical sulfonamide carbonic anhydrase (CA) inhibitors (CAIs) designed for targeting human enzymes, were also shown to effectively inhibit bacterial CAs and were proposed for re...
Mycobacterial β-carbonic anhydrases: Molecular biology, role in the pathogenesis of tuberculosis and inhibition studies [0.03%]
结核分枝杆菌β-碳酸酐酶：分子生物学，发病机理及抑制研究
Jenny Parkkinen,Ratul Bhowmik,Martti Tolvanen et al.
Jenny Parkkinen et al.
Mycobacterium tuberculosis (Mtb), which causes tuberculosis (TB), is still a major global health problem. According to the World Health Organization (WHO), TB still causes more deaths worldwide than any other infectious agent. Drug-sensitiv...
Reygan E Braga,Fares Z Najar,Chelsea L Murphy et al.
Reygan E Braga et al.
Carbonic anhydrases (CAs) catalyze the reversable hydration of carbon dioxide to bicarbonate placing them into the core of the biochemical carbon cycle. Due to the fundamental importance of their function, they evolved independently into ei...
Vincenzo Massimiliano Vivenzio,Davide Esposito,Simona Maria Monti et al.
Vincenzo Massimiliano Vivenzio et al.
Carbonic anhydrases belonging to the α-class are widely distributed in bacterial species. These enzymes have been isolated from bacteria with completely different characteristics including both Gram-negative and Gram-positive strains. α-C...
Katrina J Holly,Molly S Youse,Daniel P Flaherty
Katrina J Holly
Carbonic anhydrase metalloenzymes are encoded in genomes throughout all kingdoms of life with a conserved function catalyzing the reversible conversion of CO2 to bicarbonate. Carbonic anhydrases have been well-investigated in humans, but ar...
Molly S Youse,Katrina J Holly,Daniel P Flaherty
Molly S Youse
Carbonic anhydrases (CAs) are ubiquitous enzymes that are found in all kingdoms of life. Though different classes of CAs vary in their roles and structures, their primary function is to catalyze the reaction between carbon dioxide and water...
Bianca Laura Bernardoni,Concettina La Motta,Simone Carradori et al.
Bianca Laura Bernardoni et al.
Infections from Helicobacter pylori (Hp) are endangering Public Health safety worldwide, due to the associated high risk of developing severe diseases, such as peptic ulcer, gastric cancer, diabetes, and cardiovascular diseases. Current the...