Hans Robert Kalbitzer,Michael Spoerner
Hans Robert Kalbitzer
Oncogenic mutations in the Ras (rat sarcoma) protein lead to a permanent activation of the Ras pathway and are found in approximately 30% of all human tumors. During signal transduction, Ras is transiently activated by GTP binding and inter...
The allosteric switch and conformational states in Ras GTPase affected by small molecules [0.03%]
小分子影响下的Ras GTP酶变构开关和构象状态
Christian W Johnson,Carla Mattos
Christian W Johnson
Ras is a hub protein in signal transduction pathways leading to the control of cell proliferation, migration, and survival and a major target for drug discovery due to the presence of its mutants in about 20% of human cancers. Yet, the disc...
Till Maurer,Weiru Wang
Till Maurer
Despite decades of intense drug discovery efforts, to date no small molecules have been described that directly bind to Ras protein and effectively antagonize its function. In order to identify and characterize small-molecule binders to KRa...
Ashley L Tetlow,Fuyuhiko Tamanoi
Ashley L Tetlow
The Ras superfamily G-proteins are monomeric proteins of approximately 21kDa that act as a molecular switch to regulate a variety of cellular processes. The structure of the Ras superfamily G-proteins, their regulators as well as posttransl...