Plasma PAFAH/PLA2G7 Genetic Variability, Cardiovascular Disease, and Clinical Trials [0.03%]
血浆PAFAH/PLA2G7遗传变异、心血管疾病与临床试验
Sonia Karabina,Ewa Ninio
Sonia Karabina
PAFAH is specific for short acyl groups esterified at the sn-2 position of glycerol in phospholipids, and apart from PAF, it hydrolyzes oxidized phospholipids produced during LDL oxidation. As the majority of the plasma PAFAH activity is bo...
Naturally Occurring Missense Mutation in Plasma PAF-AH Among the Japanese Population [0.03%]
日本人中血浆PAF-AH天然错义变异的缺失型多态性研究
Ken Karasawa
Ken Karasawa
A single nucleotide polymorphism in the plasma PAF-AH enzyme, i.e., G994T, which causes the substitution of Val at amino acid 279 with Phe (V279F), has been found in the Japanese population. This enzyme preferentially degrades oxidatively m...
Tara D Gonzalez,Brian J Bahnson
Tara D Gonzalez
The structure of plasma PAF-AH was solved to a resolution of 1.5Å using X-ray crystallography. The enzyme has a classic α/β serine hydrolase fold containing a catalytic triad of Ser273, Asp296, and His351. A hydrophobic patch of the enzy...
Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression [0.03%]
血浆PAF-AH(PAL2G7):生化性质、与LDL和HDL的相互作用及其表达调控
Diana M Stafforini
Diana M Stafforini
This chapter is focused on the plasma form of PAF-acetylhydrolase (PAF-AH), a lipoprotein-bound, calcium-independent phospholipase A2 activity also referred to as lipoprotein-associated phospholipase A2 and PLA2G7. PAF-AH catalyzes the remo...
Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II [0.03%]
关于板甲活化因子乙酰水解酶型II的运输和寡聚调节研究
Meghan M Klems,Brian J Bahnson
Meghan M Klems
Platelet-activating factor acetylhydrolase type II, PAFAH-II, is an intracellular phospholipase A2 enzyme present in various tissues and cells. PAFAH-II hydrolyzes a known phospholipid-derived mediator, platelet-activating factor, as well a...
Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That Hydrolyzes Oxidatively Modified Phospholipids [0.03%]
细胞内血小板活化因子乙酰水解酶，II型：一种独特的可使氧化性磷脂发生水解的细胞磷脂酶A2
Nozomu Kono,Hiroyuki Arai
Nozomu Kono
Intracellular platelet-activating factor acetylhydrolase, type II [PAF-AH (II)] is a monomeric 40kDa enzyme that was originally purified as an enzyme that hydrolyzes the acetyl group of PAF (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine). ...
Platelet-Activating Factor Acetylhydrolase and Brain Development [0.03%]
platelet-activating factor acetylhydrolase和大脑发育
Gary D Clark
Gary D Clark
The heterotrimeric brain platelet-activating factor acetylhydrolase (PAFAH1B1) contains two catalytic subunits and a regulatory subunit. This complex plays important, surprising roles in brain development and in spermatogenesis. The regulat...
Mitsuharu Hattori,Hiroyuki Arai
Mitsuharu Hattori
Platelet-activating factor (PAF) is a phospholipid mediator whose synthesis and degradation depend on specific sets of enzymes. PAF-acetylhydrolase (PAF-AH) hydrolyzes the acetyl moiety of PAF at its sn-2 position and thereby inactivates it...
Ken Karasawa,Keizo Inoue
Ken Karasawa
Because the acetyl group of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) is essential for its biological activity, the degradation of PAF is the most important mechanism that regulates the level of PAF. The enzyme that catalyzes the...
S Zahra Bathaie,Fuyuhiko Tamanoi
S Zahra Bathaie
Editorial
The Enzymes. 2015:37:xiii. DOI:10.1016/S1874-6047(15)00017-7 2015