Federico Forneris,Claudia Binda,MariaAntonietta Vanoni et al.
Federico Forneris et al.
Histone lysine methylation is one of the posttranslational modifications involved in transcriptional regulation and chromatin remodeling. The first lysine specific histone demethylase (LSD1) has been recently discovered, whichrules out the ...
7 Non-histone protein lysine methyltransferases: Structure and catalytic roles [0.03%]
七种非组蛋白赖氨酸甲基转移酶：结构和催化作用
Lynnette M A Dirk,Raymond C Trievel,Robert L Houtz
Lynnette M A Dirk
Non-histone protein lysine methyltransferases (PKMTs) represent an exceptionally diverse and large group of PKMTs. Even accepting the possibility of multiple protein substrates, if the number of different proteins with methylated lysyl resi...
Bing Xiao,Steven J Gamblin,Jonathan R Wilson
Bing Xiao
Methylation of lysine residues is now understood to constitute a key component of the complex signaling paradigm referred to as the histone code hypothesis. Rapid progress has been made in the structural and functional biology of the enzyme...
5 Methylation and demethylation of his tone arg and lys residues in chromatin structure and function [0.03%]
组蛋白精氨酸和赖氨酸残基的甲基化和去甲基化在染色质结构与功能中的作用
Yanming Wang
Yanming Wang
Chromatin is the physiological template of all eukaryotic genomic activities. Histone proteins are the fundamental building elements of chromatin, which are the subject of various posttranslational modifications, including methylation. Addi...
Xing Zhang,Xiaodong Cheng
Xing Zhang
With genome sequencing nearing completion for the modelorganisms used in biomedical research, there is a rapidly growing appreciation that proteomics (including the study of covalent modification to proteins) and transcriptional regulation ...
Anne E McBride
Anne E McBride
Methylation of arginine residues within proteins results in a more subtle change than phosphorylation, but one that also has profound impacts on eukaryotic organisms. The rapidly expanding list of protein arginine methyltransferases (PRMTs)...
Mark T Bedford
Mark T Bedford
Arginine methylation is a widespread posttranslational modification found on both nuclear and cytoplasmic proteins. The methylation of arginine residues is catalyzed by the protein arginine N-methyltransferase (PRMT) family of enzymes, of w...
1 Protein Methyltransferases: Their Distribution Among the Five Structural Classes of AdoMet-Dependent Methyltransferases [0.03%]
甲基转移酶：其在五种结构类型的AdoMet依赖型甲基转移酶中的分布
Heidi L Schubert,Robert M Blumenthal,Xiaodong Cheng
Heidi L Schubert
S-adenosyl-l-methionine (AdoMet) dependent methyltransferases (MTases) are involved in biosynthesis, signal transduction, protein repair, chromatin regulation, and gene silencing. Five different structural folds (designated I through V) hav...
Keizo Inoue,Diana Stafforini,Fuyuhiko Tamanoi
Keizo Inoue
Editorial
The Enzymes. 2015:38:xi. DOI:10.1016/S1874-6047(15)00040-2 2015
Diana M Stafforini
Diana M Stafforini
This chapter is focused on the role of the plasma form of platelet-activating factor-acetylhydrolase (PAF-AH), heretofore referred to as PAF-AH, in tumorigenic responses. Biochemical and other properties of this enzyme were discussed in det...