Shahla Shojaei,Amir Kiumarsi,Adel Rezaei Moghadam et al.
Shahla Shojaei et al.
Natural products have a long history of use in traditional medicines and their activities against different diseases have been the focus of many basic and clinical researches in past few decades. The essential oils, volatile liquid containi...
Introduction [0.03%]
绪论
S Zahra Bathaie,Fuyuhiko Tamanoi
S Zahra Bathaie
Natural products and phytochemicals have extensively attracted for their various biological effects, especially for both treatment and prevention of cancer. In this book, we try to introduce various phytochemicals as cancer therapy targets ...
16 Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary same? [0.03%]
5'-甲基硫oadenosine(MTA)抑制哺乳动物蛋白甲基转移酶的作用机制：是饮食相同的作用机理吗？
Steven G Clarke
Steven G Clarke
5'-deoxy-5'-methylthioadenosine (5'-methylthioadenosine, MTA) is a naturally occurring metabolite. As an experimental reagent, it has proved useful in providing investigators a window onto the role of protein methylation reactions in intact...
Alan V Klotz
Alan V Klotz
Side-chain amide methylation of asparagine was described in a special complement of photosynthesis accessory pigment-protein complexes called phycobiliproteins nearly 20 years ago. Since that report, several investigations have assigned thi...
14 Modification of glutamine residues in proteins involved in translation [0.03%]
参与翻译过程的蛋白质中谷氨酰胺残基的修饰
Heidi L Schubert
Heidi L Schubert
The only known protein glutamine methylations take place on proteins related to the ribosomal function. The modification is a mono-methylation on the side-chain amide nitrogen (N5). The glutamine residue within a Gly-Gly-Gln (GGQ) motif of ...
13 Protein L-isoaspartyl, D-aspartyl O-methyltransferases: Catalysts for protein repair [0.03%]
蛋白质L-异天冬氨酸，D-天冬氨酸O-甲基转移酶：蛋白质修复催化剂
Clare M O&#x;Connor
Clare M O&#x;Connor
Protein L-isoaspartyl, D-aspartyl O-methyltransferases (PIMTs) are ancient enzymes distributed through all phylogenetic domains. PIMTs catalyze the methylation of L-isoaspartyl, and to a lesser extent D-aspartyl, residues arising from the s...
12 Reversible methylation of glutamate residues in the receptor proteins of bacterial sensory systems [0.03%]
glutamate残基在细菌感觉系统受体蛋白中的可逆甲基化
Frances M Antommattei,Robert M Weis
Frances M Antommattei
The methyltransferase CheR catalyzes methyl group transfer from S-adenosyl-l-methionine to specific glutamic acid side chains of bacterial chemoreceptors, referred to as the methyl-accepting chemotaxis proteins (MCPs). A second enzyme, the ...
Sari Longin,Jozef Goris
Sari Longin
PP2A has been shown to be methylated at the C-terminal leucine residue of the catalytic subunit by a specific 38 kDa methyltransferase (LCMT1) and demethylated by a specific 44-kDa methylesterase (PME-1). This reversible methylation does no...
10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins [0.03%]
10 种遗传学方法研究异戊二烯化蛋白质羧基甲基化生理作用的重要性
Stephen G Young,Steven G Clarke,Martin O Bergoc et al.
Stephen G Young et al.
This chapter examines recent studies on the physiologic importance of the carboxyl methylation of isoprenylated proteins, focusing largely on what has been learned from cells lacking the Icmt methyltransferase. Proteins terminating with a C...
9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing [0.03%]
异戊烯半胱氨酸羧基甲基转移酶(Icmt)的结构与功能：CaaX加工中的关键酶
Jessica L Anderson,Christine A Hrycyna
Jessica L Anderson
Proteins that terminate in a C-terminal CaaX motif undergo three sequential posttranslational modifications: isoprenylation of the cysteine residue, endoproteolysis of the -aaX residues, and methylation of the isoprenylated cysteine by an i...