S Chodavarapu,J M Kaguni
S Chodavarapu
The initiation of chromosomal DNA replication starts at a replication origin, which in bacteria is a discrete locus that contains DNA sequence motifs recognized by an initiator protein whose role is to assemble the replication fork machiner...
Guillaume Chanfreau,Fuyuhiko Tamanoi
Guillaume Chanfreau
The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism [0.03%]
真菌RNase III酶在RNA代谢中的多种功能
Kevin Roy,Guillaume F Chanfreau
Kevin Roy
Enzymes from the ribonuclease III family bind and cleave double-stranded RNA to initiate RNA processing and degradation of a large number of transcripts in bacteria and eukaryotes. This chapter focuses on the description of the diverse func...
Christiane Harnisch,Bodo Moritz,Christiane Rammelt et al.
Christiane Harnisch et al.
Shortening of the poly(A) tail is the first and often rate-limiting step in mRNA degradation. Three poly(A)-specific 3' exonucleases have been described that can carry out this reaction: PAN, composed of two subunits; PARN, a homodimer; and...
Megerditch Kiledjian,Mi Zhou,Xinfu Jiao
Megerditch Kiledjian
Messenger RNAs transcribed by RNA polymerase II are modified at their 5'-end by the cotranscriptional addition of a 7-methylguanosine (m(7)G) cap. The cap is an important modulator of gene expression and the mechanism and components involve...
Rat1 and Xrn2: The Diverse Functions of the Nuclear Rat1/Xrn2 Exonuclease [0.03%]
Rat1和Xrn2：核酶Rat1/Xrn2的多种功能
Michal Krzyszton,Monika Zakrzewska-Placzek,Michal Koper et al.
Michal Krzyszton et al.
The role of the nucleus of a eukaryotic cell during gene expression is not only limited to transcription and RNA processing but also includes the initial stages of RNA surveillance. All of these processes, and more precisely, transcription ...
Jeong Ho Chang,Song Xiang,Liang Tong
Jeong Ho Chang
5'-3' Exoribonucleases (XRNs) have important functions in RNA processing, RNA turnover and decay, RNA interference, RNA polymerase transcription, and other cellular processes. Their sequences share two highly conserved regions, CR1 and CR2....
Sarah Geisler,Jeff Coller
Sarah Geisler
The degradation of RNA is a critical aspect of gene regulation. Correspondingly, ribonucleases exist within the cell to degrade RNA in specific cellular contexts. An important and conserved ribonuclease is called XRN1. This enzyme, an exori...
Peter Holub,Stepanka Vanacova
Peter Holub
In order to control and/or enhance the specificity and activity of nuclear surveillance and degradation, exosomes cooperate with the polyadenylation complex called TRAMP. Two forms of TRAMP operate in budding yeast, TRAMP4 and TRAMP5. They ...
Elizabeth V Wasmuth,Christopher D Lima
Elizabeth V Wasmuth
The composition of the multisubunit eukaryotic RNA exosome was described more than a decade ago, and structural studies conducted since that time have contributed to our mechanistic understanding of factors that are required for 3'-to-5' RN...